2014
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
Shao D, Xue W, Krall E, Bhutkar A, Piccioni F, Wang X, Schinzel A, Sood S, Rosenbluh J, Kim J, Zwang Y, Roberts T, Root D, Jacks T, Hahn W. KRAS and YAP1 Converge to Regulate EMT and Tumor Survival. Cell 2014, 158: 171-184. PMID: 24954536, PMCID: PMC4110062, DOI: 10.1016/j.cell.2014.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell SurvivalColonic NeoplasmsDrug Delivery SystemsDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionHCT116 CellsHumansLung NeoplasmsMicePhosphoproteinsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsSignal TransductionTranscription FactorsTranscriptional ActivationYAP-Signaling ProteinsConceptsEpithelial-mesenchymal transitionTranscriptional regulator of epithelial-mesenchymal transitionOncogenic Ras signalingColon cancer cell linesTranscriptional coactivator YAP1KRAS-dependent cellsRegulator of epithelial-mesenchymal transitionMurine lung cancer modelTranscriptional regulationCancer cell linesMutant allelesRas signalingTranscription factor FosOncogenic RasTranscriptional programsLung cancer modelRegulating epithelial-mesenchymal transitionMolecular basisOncogenic alleleCell transformationYAP1YAP1 signalingPromote survivalCancer cellsOncogenic dependency
2010
An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells
Nikitin P, Yan C, Forte E, Bocedi A, Tourigny J, White R, Allday M, Patel A, Dave S, Kim W, Hu K, Guo J, Tainter D, Rusyn E, Luftig M. An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells. Cell Host & Microbe 2010, 8: 510-522. PMID: 21147465, PMCID: PMC3049316, DOI: 10.1016/j.chom.2010.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAtaxia Telangiectasia Mutated ProteinsB-LymphocytesCell Cycle ProteinsCell ProliferationCell Transformation, ViralCells, CulturedCheckpoint Kinase 2DNA DamageDNA-Binding ProteinsEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanHumansProtein Serine-Threonine KinasesSignal TransductionTumor Suppressor ProteinsConceptsDNA damage responseEpstein-Barr virusPrimary human B cellsHuman B cellsB cellsTumor suppressor mechanismSuppressor mechanismViral latency productsProliferating lymphoblastoid cell linesPrimary B cellsInduce cell immortalizationLymphoblastoid cell linesDDR kinase ATMEarly cell divisionsDNA damage response activationLytic viral replicationIncreased transformation efficiencyLatent episomeKinase ATMImmortalization efficiencyCell divisionHuman malignanciesDamage responseCell immortalizationViral replication