An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells
Nikitin P, Yan C, Forte E, Bocedi A, Tourigny J, White R, Allday M, Patel A, Dave S, Kim W, Hu K, Guo J, Tainter D, Rusyn E, Luftig M. An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells. Cell Host & Microbe 2010, 8: 510-522. PMID: 21147465, PMCID: PMC3049316, DOI: 10.1016/j.chom.2010.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAtaxia Telangiectasia Mutated ProteinsB-LymphocytesCell Cycle ProteinsCell ProliferationCell Transformation, ViralCells, CulturedCheckpoint Kinase 2DNA DamageDNA-Binding ProteinsEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanHumansProtein Serine-Threonine KinasesSignal TransductionTumor Suppressor ProteinsConceptsDNA damage responseEpstein-Barr virusPrimary human B cellsHuman B cellsB cellsTumor suppressor mechanismSuppressor mechanismViral latency productsProliferating lymphoblastoid cell linesPrimary B cellsInduce cell immortalizationLymphoblastoid cell linesDDR kinase ATMEarly cell divisionsDNA damage response activationLytic viral replicationIncreased transformation efficiencyLatent episomeKinase ATMImmortalization efficiencyCell divisionHuman malignanciesDamage responseCell immortalizationViral replication