2000
A Clinicopathologic Study of 45 Pediatric Soft Tissue Tumors With an Admixture of Adipose Tissue and Fibroblastic Elements, and a Proposal for Classification as Lipofibromatosis
Fetsch J, Miettinen M, Laskin W, Michal M, Enzinger F. A Clinicopathologic Study of 45 Pediatric Soft Tissue Tumors With an Admixture of Adipose Tissue and Fibroblastic Elements, and a Proposal for Classification as Lipofibromatosis. The American Journal Of Surgical Pathology 2000, 24: 1491-1500. PMID: 11075850, DOI: 10.1097/00000478-200011000-00004.Peer-Reviewed Original ResearchConceptsPersistent diseaseJuvenile fibromatosisFibroblastic elementsAdipose tissueMuscle actinFibrous hamartomaAlpha-smooth muscle actinPediatric Soft TissueSkeletal muscleMitotic activityRare pediatric neoplasmSoft tissue massAbundant adipose tissueUnivacuolated cellsClinicopathologic studyInitial biopsyClinicopathologic featuresMale sexFascicular growthFocal immunoreactivityIncomplete excisionArchitectural effacementSkin adnexaCytologic atypiaPediatric neoplasmsThe “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics
Laskin W, Fetsch J, Miettinen M. The “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Human Pathology 2000, 31: 1230-1241. PMID: 11070116, DOI: 10.1053/hupa.2000.18474.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinNerve sheath myxomaSpindled cellsPeak incidenceFemale ratioLow-affinity nerve growth factor receptorDense collagenAlpha-smooth muscle actinAnti-neurofilament proteinSoft Tissue RegistryNerve sheath tumorsNerve growth factor receptorDecades of lifeEpithelial membrane antigenFibrillary acidic proteinCollagen type IV expressionGrowth factor receptorSheath tumorsAnatomic distributionLeu-7Consistent immunoreactivityMyxoid variantTissue RegistryImmunohistochemical analysisEpithelioid cells
1995
Desmoplastic malignant melanoma
Skelton H, Smith K, Laskin W, McCarthy W, Gagnier J, Graham J, Lupton G. Desmoplastic malignant melanoma. Journal Of The American Academy Of Dermatology 1995, 32: 717-725. PMID: 7722014, DOI: 10.1016/0190-9622(95)91448-x.Peer-Reviewed Original ResearchConceptsDisease-free survival ratesDesmoplastic malignant melanomaMalignant melanomaSurvival rateHistologic featuresCases of DMMOverall histologic featuresDisease-free survivalArmed Forces InstituteBetter prognosisHMB-45Histologic findingsImmunohistochemical evaluationTumor locationImmunohistochemical studyTumor depthUncommon variantBiologic potentialStromal mucinAdequate materialMelanomaTumorsRelative rarityPatientsNeural differentiation
1991
Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma)
Laskin W, Weiss S, Bratthauer G. Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma). The American Journal Of Surgical Pathology 1991, 15: 1136-1145. PMID: 1746681, DOI: 10.1097/00000478-199112000-00004.Peer-Reviewed Original ResearchConceptsNerve sheath tumorsDeep soft tissuesMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsSuperficial soft tissuesSheath tumorsSoft tissueBenign nerve sheath tumorsRounded epithelioid cellsClear cell carcinomaNeuron-specific enolaseMelanoma-associated antigensMalignant rhabdoid tumorMajority of casesVague nodulesMetastatic diseaseAsymptomatic massEpithelioid variantCell carcinomaHistologic patternFavorable coursePleomorphic sarcomaEpithelioid patternBiologic behaviorLinear immunoreactivity
1990
Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor
Kao G, Laskin W, Weiss S. Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor. Journal Of Cutaneous Pathology 1990, 17: 214-219. PMID: 1697611, DOI: 10.1111/j.1600-0560.1990.tb00088.x.Peer-Reviewed Original ResearchConceptsEccrine spiradenomaMesenchymal neoplasmsYoung adultsHistopathologic featuresMesenchymal tumorsDefinite diagnosisBiologic behaviorComplete excisionHamartomatous growthsDermal nodulesDetailed histopathologicTumorsEpithelial cellsNeoplasmsInfantsSubcutisSpiradenomaAdultsSkinInfancyDifferential featuresHistopathologicPatientsRecurrenceExcision
1989
Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases.
Kao G, Laskin W, Olsen T. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Modern Pathology 1989, 2: 20-6. PMID: 2493641.Peer-Reviewed Original ResearchConceptsBenign peripheral nerve sheath tumorsRare benign peripheral nerve sheath tumorPeripheral nerve sheath tumorsTumor cellsGlial fibrillary acid proteinSpindle-shaped tumor cellsNerve sheath tumorsNeuron-specific enolasePlexiform growth patternDistinct cytoplasmic bordersSpindle-shaped cellsVon Recklinghausen's neurofibromatosisMedian agePatient ageSheath tumorsPainful nodulesClinicopathologic correlationNerve fibersMyxoid stromaSchwann cellsNodular variantNuclear palisadingGross examinationVerocay bodiesCytoplasmic borders