2003
Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae
Lomasney L, Basu A, Demos T, Laskin W. Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae. Skeletal Radiology 2003, 32: 533-536. PMID: 12898056, DOI: 10.1007/s00256-003-0659-4.Peer-Reviewed Original Research
2001
Superficial cervicovaginal myofibroblastoma: Fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract
Laskin W, Fetsch J, Tavassoli F. Superficial cervicovaginal myofibroblastoma: Fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Human Pathology 2001, 32: 715-725. PMID: 11486170, DOI: 10.1053/hupa.2001.25588.Peer-Reviewed Original ResearchConceptsDistinctive mesenchymal tumorMesenchymal tumorsLower female genital tractTumor cellsSubepithelial stromal layerAlpha-smooth muscle actinCervix of womenFascicular growth patternFemale genital tractMuscle-specific actinAtypical mitotic figuresMesenchymal cellsEpithelial membrane antigenStroma-rich areasSuperficial lamina propriaStromal polypsLocal excisionClinicopathologic featuresAggressive angiomyxomaProgesterone receptorImmunohistochemical profileSubepithelial stromaGenital tractLamina propriaNodular massSuperficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes
Fetsch J, Laskin W, Miettinen M. Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Human Pathology 2001, 32: 704-714. PMID: 11486169, DOI: 10.1053/hupa.2001.25903.Peer-Reviewed Original ResearchConceptsSoft tissue tumorsDistinctive soft tissue tumorLocal excisionTissue tumorsAcral myxoinflammatory fibroblastic sarcomaFascicular growth patternEpithelial membrane antigenMild nuclear atypiaMyxoinflammatory fibroblastic sarcomaStellate-shaped cellsProgressive diseaseClinicopathologic featuresHMB-45Surgical interventionImmunohistochemical findingsResection specimensSurgical specimensFibrous histiocytomaPartial excisionDifferential diagnosisLesional cellsStudy groupMast cellsNuclear atypiaImmunohistochemical analysis
2000
A Clinicopathologic Study of 45 Pediatric Soft Tissue Tumors With an Admixture of Adipose Tissue and Fibroblastic Elements, and a Proposal for Classification as Lipofibromatosis
Fetsch J, Miettinen M, Laskin W, Michal M, Enzinger F. A Clinicopathologic Study of 45 Pediatric Soft Tissue Tumors With an Admixture of Adipose Tissue and Fibroblastic Elements, and a Proposal for Classification as Lipofibromatosis. The American Journal Of Surgical Pathology 2000, 24: 1491-1500. PMID: 11075850, DOI: 10.1097/00000478-200011000-00004.Peer-Reviewed Original ResearchConceptsPersistent diseaseJuvenile fibromatosisFibroblastic elementsAdipose tissueMuscle actinFibrous hamartomaAlpha-smooth muscle actinPediatric Soft TissueSkeletal muscleMitotic activityRare pediatric neoplasmSoft tissue massAbundant adipose tissueUnivacuolated cellsClinicopathologic studyInitial biopsyClinicopathologic featuresMale sexFascicular growthFocal immunoreactivityIncomplete excisionArchitectural effacementSkin adnexaCytologic atypiaPediatric neoplasmsThe “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics
Laskin W, Fetsch J, Miettinen M. The “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Human Pathology 2000, 31: 1230-1241. PMID: 11070116, DOI: 10.1053/hupa.2000.18474.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinNerve sheath myxomaSpindled cellsPeak incidenceFemale ratioLow-affinity nerve growth factor receptorDense collagenAlpha-smooth muscle actinAnti-neurofilament proteinSoft Tissue RegistryNerve sheath tumorsNerve growth factor receptorDecades of lifeEpithelial membrane antigenFibrillary acidic proteinCollagen type IV expressionGrowth factor receptorSheath tumorsAnatomic distributionLeu-7Consistent immunoreactivityMyxoid variantTissue RegistryImmunohistochemical analysisEpithelioid cells
1999
Colposcopy in pregnancy: directed brush cytology compared with cervical biopsy.
Lieberman R, Henry M, Laskin W, Walenga J, Buckner S, O'Connor D. Colposcopy in pregnancy: directed brush cytology compared with cervical biopsy. Obstetrics And Gynecology 1999, 94: 198-203. PMID: 10432127, DOI: 10.1016/s0029-7844(99)00283-5.Peer-Reviewed Original ResearchConceptsSquamous intraepithelial lesionsBrush cytologyPregnant patientsAcetowhite lesionsHigh-grade squamous intraepithelial lesionsCervical intraepithelial neoplasia IIHuman papillomavirus effectAbnormal cervical cytologyAtypical squamous cellsIntrauterine fetal deathLess blood lossTime of biopsyAbsence of lesionsColposcopic evaluationBlood lossFetal deathIntraepithelial lesionsCervical biopsiesThird trimesterSquamous cellsCervical cytologyStudy groupUncertain causeBiopsyPatientsNuchal fibrocartilaginous pseudotumor: a clinicopathologic study of five cases and review of the literature.
Laskin W, Fetsch J, Miettinen M. Nuchal fibrocartilaginous pseudotumor: a clinicopathologic study of five cases and review of the literature. Modern Pathology 1999, 12: 663-8. PMID: 10430269.Peer-Reviewed Original ResearchConceptsNuchal fibrocartilaginous pseudotumorEnglish-language medical literatureVague neck painEvidence of recurrentSoft tissueHistory of headComplete local excisionNuchal ligamentDeep soft tissuesChronic mechanical stressLower cervical vertebraeNeck painClinicopathologic studyPersistent diseaseLocal excisionNeck traumaNodular proliferationSimple excisionFibrocartilaginous massCytologic atypiaPosterior aspectNodular massBenign lesionsFibrocartilaginous metaplasiaMedical literature
1998
Angiomyofibroblastomalike Tumor of the Male Genital Tract
Laskin W, Fetsch J, Mostofi F. Angiomyofibroblastomalike Tumor of the Male Genital Tract. The American Journal Of Surgical Pathology 1998, 22: 6-16. PMID: 9422311, DOI: 10.1097/00000478-199801000-00002.Peer-Reviewed Original ResearchConceptsMale genital tractSpindle cell lipomaClinicopathologic featuresGenital tractCell lipomaRecurrent/persistent diseaseGenital tract tumorsProgesterone receptor proteinMuscle-specific actinMedium-sized vesselsMild nuclear atypiaSoft tissue neoplasmSmooth muscle actinEstrogen receptor proteinReceptor proteinPersistent diseaseTract tumorsAbnormal mitotic figuresFocal findingsSimple excisionIntralesional fatSpindled cellsCollagenous stromaInguinal regionNuclear atypia
1997
Superficial Angiomyxoma (Cutaneous Myxoma) A Clinicopathologic Study of 17 Cases Arising in the Genital Region
Fetsch J, Laskin W, Tavassoli F. Superficial Angiomyxoma (Cutaneous Myxoma) A Clinicopathologic Study of 17 Cases Arising in the Genital Region. International Journal Of Gynecological Pathology 1997, 16: 325-334. PMID: 9421071, DOI: 10.1097/00004347-199710000-00006.Peer-Reviewed Original ResearchConceptsSuperficial angiomyxomaGenital regionGlial fibrillary acidic proteinSite of involvementMuscle-specific actinFibrillary acidic proteinSmooth muscle actinYears 11 monthsMedian followClinicopathologic studyMale patientsAntigen modulationProgesterone receptorFibroblast-like cellsPainless massLabium majusEstrogen receptorMedical attentionPatientsMuscle actinS100 proteinCarney complexAcidic proteinMons pubisAngiomyxomaAngiomyofibroblastoma of the female genital tract: Analysis of 17 cases including a lipomatous variant
Laskin W, Fetsch J, Tavassoli F. Angiomyofibroblastoma of the female genital tract: Analysis of 17 cases including a lipomatous variant. Human Pathology 1997, 28: 1046-1055. PMID: 9308729, DOI: 10.1016/s0046-8177(97)90058-7.Peer-Reviewed Original ResearchConceptsHigh-power fieldLipomatous variantGenital tractCanal of NuckProgesterone receptor proteinFemale genital tractCase of angiomyofibroblastomaMedium-sized vesselsSmooth muscle actinEstrogen receptor proteinMinimal nuclear atypiaReceptor proteinAbnormal mitotic figuresPainless massSimple excisionImmunohistochemical profilePerivascular stem cellsIntralesional fatNuclear atypiaVulvar regionMuscle actinAngiomyofibroblastomaBenign natureMorphological spectrumTumor cells
1996
Aggressive angiomyxoma: A clinicopathologic study of 29 female patients
Fetsch J, Laskin W, Lefkowitz M, Kindblom L, Meis‐Kindblom J. Aggressive angiomyxoma: A clinicopathologic study of 29 female patients. Cancer 1996, 78: 79-90. PMID: 8646730, DOI: 10.1002/(sici)1097-0142(19960701)78:1<79::aid-cncr13>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsAggressive angiomyxomaSmooth muscle differentiationInitial resectionMesenchymal tumorsNeoplastic cellsFocal smooth muscle differentiationTumor related deathUncommon mesenchymal tumorMuscle-specific actinArmed Forces InstituteAbundant eosinophilic cytoplasmSmooth muscle actinClinicopathologic studyLocal recurrenceMetastatic diseaseFemale patientsPathologic featuresRecurrent tumorsPeak incidenceProgesterone receptorRelated deathsEosinophilic cytoplasmSpindled cellsMyofibroblastic featuresEdema fluid
1995
Desmoplastic malignant melanoma
Skelton H, Smith K, Laskin W, McCarthy W, Gagnier J, Graham J, Lupton G. Desmoplastic malignant melanoma. Journal Of The American Academy Of Dermatology 1995, 32: 717-725. PMID: 7722014, DOI: 10.1016/0190-9622(95)91448-x.Peer-Reviewed Original ResearchConceptsDisease-free survival ratesDesmoplastic malignant melanomaMalignant melanomaSurvival rateHistologic featuresCases of DMMOverall histologic featuresDisease-free survivalArmed Forces InstituteBetter prognosisHMB-45Histologic findingsImmunohistochemical evaluationTumor locationImmunohistochemical studyTumor depthUncommon variantBiologic potentialStromal mucinAdequate materialMelanomaTumorsRelative rarityPatientsNeural differentiation
1994
Epithelioid hemangioendothelioma with multiple site involvement. Literature review and observations
Bollinger B, Laskin W, Knight C. Epithelioid hemangioendothelioma with multiple site involvement. Literature review and observations. Cancer 1994, 73: 610-615. PMID: 7507796, DOI: 10.1002/1097-0142(19940201)73:3<610::aid-cncr2820730318>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsEpithelioid hemangioendotheliomaLung involvementLow-grade epithelioid hemangioendotheliomaLow-grade histologic typeFactor VIII-related antigenBilateral lung involvementIntense combination chemotherapyMultiple lytic lesionsAggressive histologic featuresMultiple site involvementVIII-related antigenEpithelioid-appearing cellsIntermediate cytoplasmic filamentsScalp involvementMetastatic diseaseCombination chemotherapyLytic lesionsHistologic typeHistologic featuresRadiographic findingsFemale sexProgesterone receptorMyxohyaline stromaImmunohistochemical reactivityRole of hormones
1991
Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma)
Laskin W, Weiss S, Bratthauer G. Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma). The American Journal Of Surgical Pathology 1991, 15: 1136-1145. PMID: 1746681, DOI: 10.1097/00000478-199112000-00004.Peer-Reviewed Original ResearchConceptsNerve sheath tumorsDeep soft tissuesMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsSuperficial soft tissuesSheath tumorsSoft tissueBenign nerve sheath tumorsRounded epithelioid cellsClear cell carcinomaNeuron-specific enolaseMelanoma-associated antigensMalignant rhabdoid tumorMajority of casesVague nodulesMetastatic diseaseAsymptomatic massEpithelioid variantCell carcinomaHistologic patternFavorable coursePleomorphic sarcomaEpithelioid patternBiologic behaviorLinear immunoreactivity
1989
Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases.
Kao G, Laskin W, Olsen T. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Modern Pathology 1989, 2: 20-6. PMID: 2493641.Peer-Reviewed Original ResearchConceptsBenign peripheral nerve sheath tumorsRare benign peripheral nerve sheath tumorPeripheral nerve sheath tumorsTumor cellsGlial fibrillary acid proteinSpindle-shaped tumor cellsNerve sheath tumorsNeuron-specific enolasePlexiform growth patternDistinct cytoplasmic bordersSpindle-shaped cellsVon Recklinghausen's neurofibromatosisMedian agePatient ageSheath tumorsPainful nodulesClinicopathologic correlationNerve fibersMyxoid stromaSchwann cellsNodular variantNuclear palisadingGross examinationVerocay bodiesCytoplasmic borders
1988
Postradiation soft tissue sarcomas: An analysis of 53 cases
Laskin W, Silverman T, Enzinger F. Postradiation soft tissue sarcomas: An analysis of 53 cases. Cancer 1988, 62: 2330-2340. PMID: 3179948, DOI: 10.1002/1097-0142(19881201)62:11<2330::aid-cncr2820621113>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsMalignant fibrous histiocytomaLatency periodMegavoltage radiationTime of diagnosisMean radiation doseSoft tissue sarcomasTypes of sarcomasShort latency periodAdministered radiationClinical characteristicsPatient ageSecondary sarcomaClinicopathologic featuresDismal prognosisExtraskeletal osteosarcomaPatient survivalTissue sarcomasMalignant schwannomaOrthovoltage radiationFibrous histiocytomaExtraskeletal chondrosarcomaSex incidenceMalignant processPatientsSarcomaMalignant Fibrous Histiocytoma Associated with Hyperlipoproteinemia
Laskin W, Conklin R, Enzinger F. Malignant Fibrous Histiocytoma Associated with Hyperlipoproteinemia. The American Journal Of Surgical Pathology 1988, 12: 727-732. PMID: 2843059, DOI: 10.1097/00000478-198809000-00010.Peer-Reviewed Original ResearchConceptsMalignant fibrous histiocytomaXanthoma cellsFibrous histiocytomaTumor cellsDistinct storiform patternMalignant Fibrous Histiocytoma AssociatedUnusual histologic featuresXanthomatous changesHistologic featuresTuberous xanthomasStoriform patternMalignant tumorsAtypical nucleiCholesterol depositsPleomorphic cellsUnique caseHyperlipoproteinemiaHistiocytomaTumorsUniform stainingCommon mesenchymal precursorStainingMesenchymal precursorsCellsPatients