2001
Follicular dendritic cell tumor presenting in the lung: A case report
Shah R, Ozden O, Yeldandi A, Peterson L, Rao S, Laskin W. Follicular dendritic cell tumor presenting in the lung: A case report. Human Pathology 2001, 32: 745-749. PMID: 11486174, DOI: 10.1053/hupa.2001.25595.Peer-Reviewed Original ResearchConceptsFollicular dendritic cell sarcomaEpstein-Barr virusExtranodal follicular dendritic cell sarcomaTumor cellsLow-affinity nerve growth factor receptorDendritic cell sarcomaHilar lymph nodesChronic inflammatory cellsBronchial biopsy specimensComplement receptor CD21Nerve growth factor receptorMuscle-specific actinGrowth factor receptorLymph nodesTumor PresentingCell sarcomaInflammatory cellsCase reportBiopsy specimensPolymerase chain reactionImmunohistochemical panelPleural nodulesDifferential diagnosisPlasma cellsSpindled cells
2000
The “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics
Laskin W, Fetsch J, Miettinen M. The “neurothekeoma”: Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Human Pathology 2000, 31: 1230-1241. PMID: 11070116, DOI: 10.1053/hupa.2000.18474.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinNerve sheath myxomaSpindled cellsPeak incidenceFemale ratioLow-affinity nerve growth factor receptorDense collagenAlpha-smooth muscle actinAnti-neurofilament proteinSoft Tissue RegistryNerve sheath tumorsNerve growth factor receptorDecades of lifeEpithelial membrane antigenFibrillary acidic proteinCollagen type IV expressionGrowth factor receptorSheath tumorsAnatomic distributionLeu-7Consistent immunoreactivityMyxoid variantTissue RegistryImmunohistochemical analysisEpithelioid cells
1998
Angiomyofibroblastomalike Tumor of the Male Genital Tract
Laskin W, Fetsch J, Mostofi F. Angiomyofibroblastomalike Tumor of the Male Genital Tract. The American Journal Of Surgical Pathology 1998, 22: 6-16. PMID: 9422311, DOI: 10.1097/00000478-199801000-00002.Peer-Reviewed Original ResearchConceptsMale genital tractSpindle cell lipomaClinicopathologic featuresGenital tractCell lipomaRecurrent/persistent diseaseGenital tract tumorsProgesterone receptor proteinMuscle-specific actinMedium-sized vesselsMild nuclear atypiaSoft tissue neoplasmSmooth muscle actinEstrogen receptor proteinReceptor proteinPersistent diseaseTract tumorsAbnormal mitotic figuresFocal findingsSimple excisionIntralesional fatSpindled cellsCollagenous stromaInguinal regionNuclear atypia
1997
Superficial Angiomyxoma (Cutaneous Myxoma) A Clinicopathologic Study of 17 Cases Arising in the Genital Region
Fetsch J, Laskin W, Tavassoli F. Superficial Angiomyxoma (Cutaneous Myxoma) A Clinicopathologic Study of 17 Cases Arising in the Genital Region. International Journal Of Gynecological Pathology 1997, 16: 325-334. PMID: 9421071, DOI: 10.1097/00004347-199710000-00006.Peer-Reviewed Original ResearchConceptsSuperficial angiomyxomaGenital regionGlial fibrillary acidic proteinSite of involvementMuscle-specific actinFibrillary acidic proteinSmooth muscle actinYears 11 monthsMedian followClinicopathologic studyMale patientsAntigen modulationProgesterone receptorFibroblast-like cellsPainless massLabium majusEstrogen receptorMedical attentionPatientsMuscle actinS100 proteinCarney complexAcidic proteinMons pubisAngiomyxomaAngiomyofibroblastoma of the female genital tract: Analysis of 17 cases including a lipomatous variant
Laskin W, Fetsch J, Tavassoli F. Angiomyofibroblastoma of the female genital tract: Analysis of 17 cases including a lipomatous variant. Human Pathology 1997, 28: 1046-1055. PMID: 9308729, DOI: 10.1016/s0046-8177(97)90058-7.Peer-Reviewed Original ResearchConceptsHigh-power fieldLipomatous variantGenital tractCanal of NuckProgesterone receptor proteinFemale genital tractCase of angiomyofibroblastomaMedium-sized vesselsSmooth muscle actinEstrogen receptor proteinMinimal nuclear atypiaReceptor proteinAbnormal mitotic figuresPainless massSimple excisionImmunohistochemical profilePerivascular stem cellsIntralesional fatNuclear atypiaVulvar regionMuscle actinAngiomyofibroblastomaBenign natureMorphological spectrumTumor cellsAn intra-abdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS/FLI-1 fusion transcript
Katz R, Quezado M, Senderowicz A, Villalba L, Laskin W, Tsokos M. An intra-abdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS/FLI-1 fusion transcript. Human Pathology 1997, 28: 502-509. PMID: 9104953, DOI: 10.1016/s0046-8177(97)90042-3.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdultBiomarkersBlotting, WesternCarcinoma, Small CellDesminDNA-Binding ProteinsFatal OutcomeHumansImmunohistochemistryKeratinsMaleMicroscopy, ElectronNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionPolymerase Chain ReactionProto-Oncogene Protein c-fli-1Proto-Oncogene ProteinsSarcoma, EwingTomography, X-Ray ComputedTrans-ActivatorsConceptsDesmoplastic round cell tumorPeripheral primitive neuroectodermal tumorRound cell tumorCell tumorsSmall round cell neoplasmsPNET/Ewing's sarcomaEWS/FLIHybrid tumorsRound cell neoplasmsPrimitive neuroectodermal tumorFusion transcriptsTranscription-polymerase chain reactionNeuroectodermal tumorPolymerase chain reactionCell neoplasmsEwing's sarcomaImmunophenotypic profilePeritoneal cavityCommon histogenesisElectron microscopic appearanceTumorsUnique caseYoung malesMicroscopic appearanceMIC2 protein
1995
Desmoplastic malignant melanoma
Skelton H, Smith K, Laskin W, McCarthy W, Gagnier J, Graham J, Lupton G. Desmoplastic malignant melanoma. Journal Of The American Academy Of Dermatology 1995, 32: 717-725. PMID: 7722014, DOI: 10.1016/0190-9622(95)91448-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolDisease-Free SurvivalFemaleHumansImmunohistochemistryMaleMelanomaMiddle AgedSkin NeoplasmsConceptsDisease-free survival ratesDesmoplastic malignant melanomaMalignant melanomaSurvival rateHistologic featuresCases of DMMOverall histologic featuresDisease-free survivalArmed Forces InstituteBetter prognosisHMB-45Histologic findingsImmunohistochemical evaluationTumor locationImmunohistochemical studyTumor depthUncommon variantBiologic potentialStromal mucinAdequate materialMelanomaTumorsRelative rarityPatientsNeural differentiation
1994
Epithelioid hemangioendothelioma with multiple site involvement. Literature review and observations
Bollinger B, Laskin W, Knight C. Epithelioid hemangioendothelioma with multiple site involvement. Literature review and observations. Cancer 1994, 73: 610-615. PMID: 7507796, DOI: 10.1002/1097-0142(19940201)73:3<610::aid-cncr2820730318>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsEpithelioid hemangioendotheliomaLung involvementLow-grade epithelioid hemangioendotheliomaLow-grade histologic typeFactor VIII-related antigenBilateral lung involvementIntense combination chemotherapyMultiple lytic lesionsAggressive histologic featuresMultiple site involvementVIII-related antigenEpithelioid-appearing cellsIntermediate cytoplasmic filamentsScalp involvementMetastatic diseaseCombination chemotherapyLytic lesionsHistologic typeHistologic featuresRadiographic findingsFemale sexProgesterone receptorMyxohyaline stromaImmunohistochemical reactivityRole of hormones
1990
Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor
Kao G, Laskin W, Weiss S. Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor. Journal Of Cutaneous Pathology 1990, 17: 214-219. PMID: 1697611, DOI: 10.1111/j.1600-0560.1990.tb00088.x.Peer-Reviewed Original ResearchConceptsEccrine spiradenomaMesenchymal neoplasmsYoung adultsHistopathologic featuresMesenchymal tumorsDefinite diagnosisBiologic behaviorComplete excisionHamartomatous growthsDermal nodulesDetailed histopathologicTumorsEpithelial cellsNeoplasmsInfantsSubcutisSpiradenomaAdultsSkinInfancyDifferential featuresHistopathologicPatientsRecurrenceExcision
1989
Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases.
Kao G, Laskin W, Olsen T. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Modern Pathology 1989, 2: 20-6. PMID: 2493641.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildFemaleHumansImmunohistochemistryMaleMicroscopy, ElectronMiddle AgedNeurilemmomaNeurofibromatosis 1ConceptsBenign peripheral nerve sheath tumorsRare benign peripheral nerve sheath tumorPeripheral nerve sheath tumorsTumor cellsGlial fibrillary acid proteinSpindle-shaped tumor cellsNerve sheath tumorsNeuron-specific enolasePlexiform growth patternDistinct cytoplasmic bordersSpindle-shaped cellsVon Recklinghausen's neurofibromatosisMedian agePatient ageSheath tumorsPainful nodulesClinicopathologic correlationNerve fibersMyxoid stromaSchwann cellsNodular variantNuclear palisadingGross examinationVerocay bodiesCytoplasmic borders