2024
Use of Mitotic Activity and the Size of Any Dedifferentiated Component for Risk Assessment in MDM2-Amplified Liposarcoma.
Wu H, Sukhanova M, Tang H, Lu X, Zhong M, Deshpande H, Pollack S, Laskin W, Alexiev B. Use of Mitotic Activity and the Size of Any Dedifferentiated Component for Risk Assessment in MDM2-Amplified Liposarcoma. Archives Of Pathology & Laboratory Medicine 2024 PMID: 39164013, DOI: 10.5858/arpa.2024-0098-oa.Peer-Reviewed Original ResearchAtypical lipomatous tumor/well-differentiated liposarcomaMDM2-amplified liposarcomasDedifferentiated componentDedifferentiated liposarcomaAdverse eventsMitotic countLocal recurrence statusMDM2 copy numberAssociated with adverse eventsLog-rank testOverall tumor volumeUnivariate logistic regressionChromosome 12q13-15Statistically significant associationPercentage of cellsTumor dimensionTumor volumeTumor sizeMDM2 proto-oncogeneClinicopathological characteristicsPathology reportsGrade 3Recurrence statusUnivariate analysisMultivariate regression modelGenomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature
Kaseb H, Tan C, Townsend J, Costa J, Laskin W. Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature. Genetic Testing And Molecular Biomarkers 2024, 28: 351-359. PMID: 39052504, DOI: 10.1089/gtmb.2024.0080.Peer-Reviewed Original ResearchWhole-exome sequencingTumor mutational burdenOsteosarcoma of boneMutational burdenGenomic landscapeDNA damage repair genesDNA homologous recombination repairLoss of heterozygosityEffects of chemotherapyPathogenic germline mutationsParaffin-embedded tissuesPrimary malignant bone tumorAnalysis of single nucleotide variantsMalignant bone tumorsRecombination repairMutagenic processesMolecular aberrationsOlder adult patientsAdult patientsSingle nucleotide variantsDNA recombinational repairGermline mutationsTumor pathogenesisFormalin-fixedHomologous recombination repairAdenocarcinoma of anogenital mammary gland type arising from encapsulated papillary carcinoma: A rare vulvar tumor mimicking breast carcinoma
Tang H, Laskin W, Luan Y, McNiff J, Zhan H. Adenocarcinoma of anogenital mammary gland type arising from encapsulated papillary carcinoma: A rare vulvar tumor mimicking breast carcinoma. Journal Of Cutaneous Pathology 2024, 51: 604-608. PMID: 38711196, DOI: 10.1111/cup.14639.Peer-Reviewed Original ResearchEncapsulated papillary carcinomaDuctal carcinoma in situAnogenital mammary-like glandsMammary-like glandsInvasive carcinomaPapillary carcinomaBreast lesionsHidradenoma papilliferumLack of myoepithelial cellsInvasive mucinous carcinomaCutaneous adnexal tumorsCarcinoma in situInvasive ductal carcinomaGland typeVulvar tumorsAdnexal tumorsMucinous carcinomaDuctal carcinomaBreast carcinomaInvasive componentPapillary proliferationHistopathological featuresRare caseSkin tumorsCystic spacesAn Unexpected Finding: A Progressive Case of Thoracic Sarcoma
Montalvo Campana M, Paredes Mogica J, Laskin W, Deshpande H. An Unexpected Finding: A Progressive Case of Thoracic Sarcoma. 2024, a6534-a6534. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6534.Peer-Reviewed Original Research
2023
Myxoinflammatory Fibroblastic Sarcoma
Wu H, Laskin W. Myxoinflammatory Fibroblastic Sarcoma. Surgical Pathology Clinics 2023, 17: 83-96. PMID: 38278610, DOI: 10.1016/j.path.2023.07.003.Peer-Reviewed Original ResearchClear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management
Alexiev B, Vormittag-Nocito E, Peabody T, Samet J, Laskin W. Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management. Human Pathology 2023, 139: 126-134. PMID: 37805864, DOI: 10.1016/j.humpath.2023.06.004.Peer-Reviewed Original ResearchConceptsClear cell chondrosarcomaDiagnosis of clear cell chondrosarcomaPrimary bone tumorsDiagnostic accuracy of core needle biopsyAccuracy of core needle biopsyBone tumorsRarest primary bone tumorsLocal recurrence rateAbundant clear cytoplasmCore needle biopsyRate of recurrenceYounger patient ageLow-grade chondrosarcomaSkeletally immature patientsMalignant cartilaginous neoplasmsDecades of lifeEpiphysis of long bonesLow diagnostic accuracyOperative resectionIncomplete excisionNeedle biopsyHistopathological diagnosisPatient ageRecurrence rateClinicopathological characteristics
2019
Soft Tissue Lesions Involving Female Reproductive Organs
Fetsch J, Laskin W. Soft Tissue Lesions Involving Female Reproductive Organs. 2019, 1405-1467. DOI: 10.1007/978-3-319-46334-6_22.Peer-Reviewed Original ResearchFemale reproductive organsCommon benign mesenchymal tumorsMalignant mesenchymal neoplasmArmed Forces InstituteSoft tissue lesionsBenign mesenchymal tumorsGynecologic tractAdult patientsTumor RegistryMesenchymal tumorsReproductive organsMesenchymal neoplasmsMesenchymal processesRarer lesionsTissue lesions
2018
Soft Tissue Lesions Involving Female Reproductive Organs
Fetsch J, Laskin W. Soft Tissue Lesions Involving Female Reproductive Organs. 2018, 1-63. DOI: 10.1007/978-1-4614-3165-7_22-2.Peer-Reviewed Original ResearchFemale reproductive organsCommon benign mesenchymal tumorsMalignant mesenchymal neoplasmArmed Forces InstituteSoft tissue lesionsBenign mesenchymal tumorsGynecologic tractAdult patientsTumor RegistryMesenchymal tumorsReproductive organsMesenchymal neoplasmsMesenchymal processesRarer lesionsTissue lesions
2017
Utility of MDM2, p16, HMB-45 and Melan A Immunohistochemistry in Differentiating Angiomyolipoma from Well-Differentiated Liposarcoma
Lin X, Laskin W, Zhang Y. Utility of MDM2, p16, HMB-45 and Melan A Immunohistochemistry in Differentiating Angiomyolipoma from Well-Differentiated Liposarcoma. Journal Of The American Society Of Cytopathology 2017, 6: s76. DOI: 10.1016/j.jasc.2017.06.190.Peer-Reviewed Original Research
2012
Perivascular epithelioid cell tumors: Recent advances
Laskin W. Perivascular epithelioid cell tumors: Recent advances. Journal Of Dr NTR University Of Health Sciences 2012, 1: 207-209. DOI: 10.4103/2277-8632.105103.Peer-Reviewed Original Research
2011
NUT midline carcinoma: a neoplasm with diagnostic challenges in cytology
Zhu B, Laskin W, Chen Y, French C, Cameron M, Nayar R, Lin X. NUT midline carcinoma: a neoplasm with diagnostic challenges in cytology. Cytopathology 2011, 22: 414-417. PMID: 21210877, DOI: 10.1111/j.1365-2303.2010.00838.x.Peer-Reviewed Original ResearchSoft Tissue Lesions Involving Female Reproductive Organs
Fetsch J, Laskin W. Soft Tissue Lesions Involving Female Reproductive Organs. 2011, 1159-1203. DOI: 10.1007/978-1-4419-0489-8_22.Peer-Reviewed Original Research
2010
Leiomyosarcoma of the Inferior Vena Cava: Clinicopathologic Study of 40 Cases
Laskin W, Fanburg-Smith J, Burke A. Leiomyosarcoma of the Inferior Vena Cava: Clinicopathologic Study of 40 Cases. Journal Of Vascular Surgery 2010, 52: 1420. DOI: 10.1016/j.jvs.2010.09.042.Peer-Reviewed Original Research
2008
Tumors and Tumor-Like Lesions of the Soft Tissues
Fanburg-Smith J, Lasota J, Auerbach A, Foss R, Laskin W, Murphey M. Tumors and Tumor-Like Lesions of the Soft Tissues. 2008, 773-949. DOI: 10.3109/9781420020373-14.Peer-Reviewed Original ResearchMETASTASIS-ASSOCIATED PROTEIN 1 AS A POTENTIAL BIOMARKER AND TARGET FOR THE MANAGEMENT OF PROSTATE CANCER BONE METASTASES
Kai L, Wang J, Chung Y, Jerrett J, Laskin W, Huang C, Satcher R, Levenson A. METASTASIS-ASSOCIATED PROTEIN 1 AS A POTENTIAL BIOMARKER AND TARGET FOR THE MANAGEMENT OF PROSTATE CANCER BONE METASTASES. Journal Of Urology 2008, 179: 390. DOI: 10.1016/s0022-5347(08)61141-6.Peer-Reviewed Original ResearchDifferential expression of neural‐cadherin in pulmonary epithelial tumours
Zynger D, Dimov N, Ho L, Laskin W, Yeldandi A. Differential expression of neural‐cadherin in pulmonary epithelial tumours. Histopathology 2008, 52: 348-354. PMID: 18269586, DOI: 10.1111/j.1365-2559.2007.02952.x.Peer-Reviewed Original ResearchConceptsLarge cell neuroendocrine carcinomaSmall cell lung carcinomaLymph node statusSquamous cell carcinomaCell neuroendocrine carcinomaCell lung carcinomaTypical carcinoidN-cadherin expressionNeuroendocrine hyperplasiaPulmonary tumorsNode statusCell carcinomaNeuroendocrine carcinomaAtypical carcinoidLung carcinomaNegative lymph node statusN-cadherinPulmonary epithelial tumorsAtypical pulmonary carcinoidsPulmonary lesionsLung lesionsPulmonary carcinoidsImmunohistochemical expressionLung tumorsEpithelial tumors
2003
Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae
Lomasney L, Basu A, Demos T, Laskin W. Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae. Skeletal Radiology 2003, 32: 533-536. PMID: 12898056, DOI: 10.1007/s00256-003-0659-4.Peer-Reviewed Original Research
2001
Follicular dendritic cell tumor presenting in the lung: A case report
Shah R, Ozden O, Yeldandi A, Peterson L, Rao S, Laskin W. Follicular dendritic cell tumor presenting in the lung: A case report. Human Pathology 2001, 32: 745-749. PMID: 11486174, DOI: 10.1053/hupa.2001.25595.Peer-Reviewed Original ResearchConceptsFollicular dendritic cell sarcomaEpstein-Barr virusExtranodal follicular dendritic cell sarcomaTumor cellsLow-affinity nerve growth factor receptorDendritic cell sarcomaHilar lymph nodesChronic inflammatory cellsBronchial biopsy specimensComplement receptor CD21Nerve growth factor receptorMuscle-specific actinGrowth factor receptorLymph nodesTumor PresentingCell sarcomaInflammatory cellsCase reportBiopsy specimensPolymerase chain reactionImmunohistochemical panelPleural nodulesDifferential diagnosisPlasma cellsSpindled cellsSuperficial cervicovaginal myofibroblastoma: Fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract
Laskin W, Fetsch J, Tavassoli F. Superficial cervicovaginal myofibroblastoma: Fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Human Pathology 2001, 32: 715-725. PMID: 11486170, DOI: 10.1053/hupa.2001.25588.Peer-Reviewed Original ResearchConceptsDistinctive mesenchymal tumorMesenchymal tumorsLower female genital tractTumor cellsSubepithelial stromal layerAlpha-smooth muscle actinCervix of womenFascicular growth patternFemale genital tractMuscle-specific actinAtypical mitotic figuresMesenchymal cellsEpithelial membrane antigenStroma-rich areasSuperficial lamina propriaStromal polypsLocal excisionClinicopathologic featuresAggressive angiomyxomaProgesterone receptorImmunohistochemical profileSubepithelial stromaGenital tractLamina propriaNodular massSuperficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes
Fetsch J, Laskin W, Miettinen M. Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Human Pathology 2001, 32: 704-714. PMID: 11486169, DOI: 10.1053/hupa.2001.25903.Peer-Reviewed Original ResearchConceptsSoft tissue tumorsDistinctive soft tissue tumorLocal excisionTissue tumorsAcral myxoinflammatory fibroblastic sarcomaFascicular growth patternEpithelial membrane antigenMild nuclear atypiaMyxoinflammatory fibroblastic sarcomaStellate-shaped cellsProgressive diseaseClinicopathologic featuresHMB-45Surgical interventionImmunohistochemical findingsResection specimensSurgical specimensFibrous histiocytomaPartial excisionDifferential diagnosisLesional cellsStudy groupMast cellsNuclear atypiaImmunohistochemical analysis