2007
Nitric Oxide as an Autocrine and Paracrine Regulator of Vessel Function
Sessa W. Nitric Oxide as an Autocrine and Paracrine Regulator of Vessel Function. 2007, 988-993. DOI: 10.1017/cbo9780511546198.111.Peer-Reviewed Original ResearchLower organismsInnate immune systemBiologyFree radical gas nitric oxideVascular biologyBlood vessel functionVessel functionGlobal importanceParacrine regulatorPeripheral nervous systemMacrophage functionGas nitric oxideBiological sciencesRobert FurchgottNitric oxideDiscoveryEnvironmental pollutantsImmune systemMammalsBiosynthesisDisparate linesNervous systemSpectrum of activityOrganismsRegulator
1991
The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen
Hecker M, Sessa W, Mitchell J, Änggård E, Vane J. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen. Journal Of Cardiovascular Pharmacology 1991, 17: s19-s24. DOI: 10.1097/00005344-199117003-00005.Peer-Reviewed Original ResearchCultured endothelial cellsBiosynthesis of EDRFRelease of EDRFEndothelial cellsNitric oxideKrebs solutionComplete urea cycleImportant regulatory factorCellular regulationExcess nitrogenVariety of cellsRegulatory factorsBiosynthesisPhysiologic buffer solutionFlow-induced releaseRelaxing factorsCytotoxic macrophagesIntracellular sourcesBrain synaptosomesEDRF biosynthesisEDRFIntracellular concentrationTransient riseCalcium ionophoreGln