2001
Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress
Paxinou E, Weisse M, Chen Q, Souza J, Hertkorn C, Selak M, Daikhin E, Yudkoff M, Sowa G, Sessa W, Ischiropoulos H. Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 11575-11580. PMID: 11562476, PMCID: PMC58771, DOI: 10.1073/pnas.201293198.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseNitric oxideOxidative stressProtective effectNitric oxide protectsNitric oxide synthaseNitric oxide synthesisECV304 cellsSteady-state levelsMechanism of protectionOxide synthaseOxide synthesisENOS cDNAHuman ECV304 cellsMitochondria respirationDeathMitochondrial respirationExposureSame extentCellsCell metabolismDynamic regulationMetabolismLow steady-state levelsGlycolytic pathway
2000
Quantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR
Fulton D, Papapetropoulos A, Zhang X, Catravas J, Hintze T, Sessa W. Quantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR. AJP Heart And Circulatory Physiology 2000, 278: h658-h665. PMID: 10666099, DOI: 10.1152/ajpheart.2000.278.2.h658.Peer-Reviewed Original ResearchConceptsENOS mRNACoronary arteryCoronary microvesselsLeft ventricleENOS cDNAEndothelial nitric oxide synthase (eNOS) mRNANitric oxide synthase mRNAEndothelial cellsCanine aortic endothelial cellsRight coronary arteryENOS mRNA levelsEndothelial cell markersCompetitive PCRAortic endothelial cellsVon Willebrand factorVein endothelial cellsInducible NOSNeuronal NOSCanine vasculatureLarge arteriesCanine Left VentricleCell markersPathophysiological statesArteryCardiac vasculature