1999
NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
Wiest R, Shah V, Sessa W, Groszmann R. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. American Journal Of Physiology 1999, 276: g1043-g1051. PMID: 10198349, DOI: 10.1152/ajpgi.1999.276.4.g1043.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Flow VelocityBlood PressureEndothelium, VascularHypertension, PortalKineticsLuminescent MeasurementsMaleMesenteric Artery, SuperiorMethoxamineNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIINitroarginineRatsRats, Sprague-DawleySplanchnic CirculationStress, MechanicalConceptsHyperdynamic splanchnic circulationSuperior mesenteric arterySplanchnic circulationSham ratsNitric oxide synthase upregulationHyperdynamic circulatory syndromeNO metabolites concentrationPortal hypertensive ratsENOS protein levelsHigh blood flowSignificant hyporesponsivenessArterial vasodilatationL-NNAPortal hypertensionPVL ratsAgonist methoxamineCirculatory syndromeENOS upregulationHypertensive ratsMesenteric arteryNomega-nitroNO inhibitorBlood flowDay 3L-arginine
1997
Regulation of Endothelial Nitric Oxide Synthase by Estrogen
Caulin-Glaser T, Sessa W, Bender J. Regulation of Endothelial Nitric Oxide Synthase by Estrogen. Ernst Schering Foundation Symposium Proceedings 1997, 217-232. DOI: 10.1007/978-3-662-03503-0_9.Peer-Reviewed Original ResearchNitric oxideL-arginineAbnormal endothelial cell functionImportant endothelium-derived vasodilatorsEndothelial nitric oxide synthaseVascular smooth muscle cell proliferationVascular smooth muscle relaxationEndothelium-derived vasodilatorsSmooth muscle cell proliferationInhibits neointima formationNitric oxide synthaseSmooth muscle relaxationDifferent NOS isoformsNitric oxide synthase regulationMuscle cell proliferationSoluble guanylate cyclaseEndothelial cell functionNitric oxide synthase (NOS) familyVascular relaxationPlatelet aggregabilityVascular diseaseEndothelial NOSOxide synthaseAntiatherogenic propertiesMuscle relaxation
1995
Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion.
Pritchard K, Groszek L, Smalley D, Sessa W, Wu M, Villalon P, Wolin M, Stemerman M. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circulation Research 1995, 77: 510-8. PMID: 7543827, DOI: 10.1161/01.res.77.3.510.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinNative low-density lipoproteinN-LDLNitro-L-arginine methyl esterNitric oxideLevels of nitrotyrosineEndothelial cell releaseEC releaseThiobarbituric acid substancesFormation of peroxynitriteSuperoxide anionENOS activityL-arginineNO productionSKF-525ANitrite productionOxidative metabolism
1994
The Nitric Oxide Synthase Family of Proteins
Sessa W. The Nitric Oxide Synthase Family of Proteins. Journal Of Vascular Research 1994, 31: 131-143. PMID: 7511942, DOI: 10.1159/000159039.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid OxidoreductasesAmino Acid SequenceAnimalsArginineCardiovascular SystemCloning, MolecularConsensus SequenceDNAGene Expression Regulation, EnzymologicHumansImmune SystemMolecular Sequence DataNervous SystemNitric OxideNitric Oxide SynthasePhosphorylationSequence AlignmentSequence Homology, Amino AcidConceptsCytochrome P450 reductase domainNitric oxide synthaseP450 reductase domainNitric oxide synthase (NOS) familySynthase familyMammalian enzymeSeparate genesReductase domainMolecular biologyNovel familyIsoforms of NOSImportant familyNitric oxideProteinEndothelial nitric oxide synthaseEnzyme nitric oxide synthaseGuanidino nitrogenImportant bio-regulatory moleculeOxide synthaseFamilyL-arginineCardiovascular systemRecent advancesGenesEnzymology
1990
L-Glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta
Swierkosz T, Mitchell J, Sessa W, Hecker M, Vane J. L-Glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta. Biochemical And Biophysical Research Communications 1990, 172: 143-148. PMID: 2222463, DOI: 10.1016/s0006-291x(05)80184-6.Peer-Reviewed Original ResearchConceptsRelease of EDRFRabbit aortic stripsAortic stripsRabbit aortaL-arginineL-ArgACh-induced relaxationEndothelium-dependent relaxationL-GlnL-Arg levelsIntact blood vesselsEDRF biosynthesisAortic tissueConsecutive infusionsEDRFL-glutamineAortaEndothelial cellsInitial equilibration periodBlood vesselsD-ArgInhibitory effectInfusionPresent studyAmino acid L-glutamineInhibition by l‐glutamine of the release of endothelium‐derived relaxing factor from cultured endothelial cells
Hecker M, Mitchell J, Swierkosz T, Sessa W, Vane J. Inhibition by l‐glutamine of the release of endothelium‐derived relaxing factor from cultured endothelial cells. British Journal Of Pharmacology 1990, 101: 237-239. PMID: 2257431, PMCID: PMC1917688, DOI: 10.1111/j.1476-5381.1990.tb12693.x.Peer-Reviewed Original Research