1993
20-Hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries
Escalante B, Omata K, Sessa W, Lee S, Falck J, Schwartzman M. 20-Hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries. European Journal Of Pharmacology 1993, 235: 1-7. PMID: 8519270, DOI: 10.1016/0014-2999(93)90812-v.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicArachidonic AcidCarotid ArteriesCattleCells, CulturedDose-Response Relationship, DrugEndothelium, VascularHydroxyeicosatetraenoic AcidsIn Vitro TechniquesMaleMesenteric ArteriesProstaglandin-Endoperoxide SynthasesRabbitsRenal ArteryVasoconstrictionVasoconstrictor AgentsConceptsBlood vesselsEndothelium-dependent vasoconstrictorEndothelial cyclooxygenaseRegulation of hemostasisVasoconstrictor metabolitesContractile potencyContractile effectAortic ringsVascular tonePlatelet functionMuscular arteriesRabbit arteriesArachidonate metabolitesPlatelet aggregationCyclooxygenaseArachidonic acidArteryBlood cellsRabbit kidneySeminal vesiclesEicosatetraenoic acidMajor arachidonate metabolitePotencyRam seminal vesiclesPresent study
1991
Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols.
Mollace V, Salvemini D, Sessa W, Vane J. Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols. Journal Of Pharmacology And Experimental Therapeutics 1991, 258: 820-3. PMID: 1716310.Peer-Reviewed Original ResearchConceptsPlatelet aggregationSodium nitroprussideAntiaggregatory effectAngiotensin-converting enzyme inhibitorOxygen-derived free radicalsInhibitors of angiotensinHuman platelet aggregationSulfhydryl-containing compoundsCyclic AMP levelsPlatelet cyclic GMPAggregatory responsePotentiating effectTeprotideAntiplatelet compoundsEnzyme inhibitorsEnalaprilatAntiaggregatory propertiesAMP levelsIloprostEndothelial cellsIntracellular scavengerNitroprussideCyclic GMPNACBovine aorta