2013
Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium
Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium. Digestive Diseases And Sciences 2013, 59: 1244-1254. PMID: 24368421, PMCID: PMC4035390, DOI: 10.1007/s10620-013-2994-1.Peer-Reviewed Original ResearchConceptsRisk of IMTamoxifen useEndoscopic gastroduodenoscopyDecreased riskGastric cancerFemale breast cancer patientsMultivariate logistic regression analysisHuman stomachHelicobacter pylori positivityBreast cancer patientsEffect of tamoxifenLogistic regression analysisHuman gastric epitheliumClinical characteristicsPylori positivityHistopathological findingsIntestinal metaplasiaPredictive factorsSydney classificationBreast surgeryCancer patientsGastric biopsiesPremalignant lesionsEstrogen exposureBiopsy site
2011
Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach
Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach. Gastroenterology 2011, 142: 21-24.e7. PMID: 22001866, PMCID: PMC3708546, DOI: 10.1053/j.gastro.2011.09.050.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAtrophyChief Cells, GastricFemaleGene Expression RegulationInjections, IntraperitonealIntegrasesLac OperonMaleMetaplasiaMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicParietal Cells, GastricSelective Estrogen Receptor ModulatorsSpecies SpecificityTamoxifenTime FactorsConceptsSelective estrogen receptor modulatorsParietal cellsBody weight doseEstrogen receptor modulatorsTamoxifen side effectsAcid secretion inhibitionZymogenic chief cellsReversible atrophyWeight doseGastric toxicityIntraperitoneal administrationReceptor modulatorsNormal miceSide effectsSecretion inhibitionGastric parietal cellsChief cellsMouse stomachTamoxifenMetaplasiaMultiple strainsToxicityCellsPatientsAtrophy
2010
Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles
Huh WJ, Mysorekar IU, Mills JC. Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles. AJP Gastrointestinal And Liver Physiology 2010, 299: g368-g380. PMID: 20413717, PMCID: PMC3774481, DOI: 10.1152/ajpgi.00021.2010.Peer-Reviewed Original ResearchConceptsInduction of CreGastric epithelial stem cellsSpasmolytic polypeptide-expressing metaplasiaFoci of hyperplasiaSubset of miceTdT-mediated dUTP nick end labelingRegenerative capacityDUTP nick end labelingNick end labelingStem cellsAntral polypsDNA damage markerChicken actin promoterEpithelial atrophyStandard dosesGastric bodyPositive apoptosisEpithelial stem cellsComplete healingProfound atrophyGastric mucosaDamage markersAdult miceLoxP-flanked allelesSevere injuries