2020
Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy
Huh WJ, Roland JT, Asai M, Kaji I. Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy. Biomedical Research 2020, 41: 113-118. PMID: 32307399, PMCID: PMC10037909, DOI: 10.2220/biomedres.41.113.Peer-Reviewed Original ResearchConceptsTuft cell numbersIntestinal tuft cellsTuft cellsAcute duodenitisPediatric patientsCeliac diseaseAge-matched normal controlsDouble-blind conditionsCell numberDuodenal ulcerSevere inflammationMucosal integrityPathological diagnosisDuodenal mucosaNormal controlsPathological specimensUseful markerInflammationNormal tissuesPatientsHuman intestineClinical interestPathological conditionsDuodenitisUlcers
2017
A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo
Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ. A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo. Cell Reports 2017, 19: 1257-1267. PMID: 28494873, PMCID: PMC5517093, DOI: 10.1016/j.celrep.2017.04.048.Peer-Reviewed Original ResearchConceptsEGF receptorEGFR localizationEndogenous regulatory elementsDistinct cell populationsReporter miceGenome editingEGFR internalizationRegulatory elementsCRISPR/C-terminusEndogenous EGFRFluorescent reportersDifferentiated compartmentVillus compartmentTraffickingCell populationsReporterExpressionEGFR expressionDisease statesDistinct patternsCompartmentsAdjacent epitheliumIntestinal tumorsAdult mice