2017
Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer
Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP. Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. Oncogenesis 2017, 6: e308-e308. PMID: 28368388, PMCID: PMC5520503, DOI: 10.1038/oncsis.2017.9.Peer-Reviewed Original ResearchConsensus molecular subtype 4Stage II colon cancerAdjuvant therapyCC patientsColon cancerRecurrence predictionWnt target gene Axin2Stage II CC patientsPoor recurrence-free survivalPoor prognosis patientsRecurrence-free survivalCpG island methylatorGene methylationPrognosis patientsCC cohortCenter cohortWorse prognosisClinical parametersPositive cancersValidation cohortMethylation-specific PCRPrognostic markerProspective mannerSubtype tumorsPrognostic biomarker
2010
Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer
Gonzalo V, Lozano JJ, Muñoz J, Balaguer F, Pellisé M, de Miguel C, Andreu M, Jover R, Llor X, Giráldez MD, Ocaña T, Serradesanferm A, Alonso-Espinaco V, Jimeno M, Cuatrecasas M, Sendino O, Castellví-Bel S, Castells A, . Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer. PLOS ONE 2010, 5: e8777. PMID: 20098741, PMCID: PMC2808250, DOI: 10.1371/journal.pone.0008777.Peer-Reviewed Original ResearchConceptsSolitary tumorSporadic CRCTumor multiplicityGene promoter methylationInflammatory bowel diseaseMultiple colorectal cancersPrevention of patientsPromoter methylationLogistic regression analysisBinomial logistic regression analysisQuantitative methylation-specific PCRAberrant gene promoter methylationCancer multiplicitySolitary CRCBowel diseasePrimary CRCColorectal cancerMultiple lesionsColorectal mucosaLynch syndromeMethylation-specific PCRPolyposis syndromeKey tumor suppressor genesHereditary syndromesExclusion criteria