Featured Publications
Size-dependent activation of CAR-T cells
Xiao Q, Zhang X, Tu L, Cao J, Hinrichs CS, Su X. Size-dependent activation of CAR-T cells. Science Immunology 2022, 7: eabl3995. PMID: 35930653, PMCID: PMC9678385, DOI: 10.1126/sciimmunol.abl3995.Peer-Reviewed Original ResearchConceptsIntermembrane spacePlasma membraneIntracellular domainExtracellular domainMolecular mechanismsLarge isoformDownstream pathwaysT cell activationVariety of cancersCaR's extracellular domainAntigen engagementAntigen receptorSize differencesCell activationActivation of CARActivationMouse lymphoma modelCD45Antigen signalCellsLymphoma modelKinasePhosphorylationCD45RABCViral infection
2020
Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling
Orbach R, Su X. Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling. Frontiers In Immunology 2020, 11: 2187. PMID: 33013920, PMCID: PMC7516127, DOI: 10.3389/fimmu.2020.02187.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAnimalsCarrier ProteinsCell LineCell MembraneCell ShapeCyclodextrinsCytokinesGlycocalyxHumansLymphocyte ActivationMembrane LipidsMembrane ProteinsMiceMicrofilament ProteinsMicroscopy, Electron, ScanningMicrovilliReceptors, Antigen, T-CellSignal TransductionStress, MechanicalSurface PropertiesSynaptosomesT-LymphocytesConceptsFunctional consequencesFinger-like membrane protrusionsT cell signalingSuper-resolution microscopyLocal membrane curvatureActin cytoskeletonMembrane protrusionsSignal transductionCell signalingMembrane curvatureCurved membranesImmune signalingBiochemical activityUnique compartmentLymphocyte microvilliMicrovillus formationCell typesLocal membraneCytoskeletonSignalingMicrovilliMembraneBody of evidenceMembrane wavesImportant role