2023
Patient experiences with tissue‐based genomic testing during active surveillance for prostate cancer
Leapman M, Sutherland R, Gross C, Ma X, Seibert T, Cooperberg M, Catalona W, Loeb S, Schulman‐Green D. Patient experiences with tissue‐based genomic testing during active surveillance for prostate cancer. BJUI Compass 2023, 5: 142-149. PMID: 38179031, PMCID: PMC10764160, DOI: 10.1002/bco2.277.Peer-Reviewed Original ResearchActive surveillanceProstate cancerGene expression testGenomic testingCancer riskPatient experienceGrade group 2 prostate cancerGleason Grade Group 1Risk prostate cancerGrade group 1Prostate cancer riskProstate cancer managementProstate cancer aggressivenessHereditary cancer riskGermline genetic testsTissue-based testsGenomic test resultsConclusions PatientsInitial biopsyPhysician recommendationPatient knowledgePatient counsellingConventional content analysisCancer managementExpression testPatient experiences with tissue-based genomic testing during active surveillance for prostate cancer.
Leapman M, Sutherland R, Gross C, Ma X, Jeong F, Seibert T, Cooperberg M, Catalona W, Loeb S, Schulman-Green D. Patient experiences with tissue-based genomic testing during active surveillance for prostate cancer. Journal Of Clinical Oncology 2023, 41: 333-333. DOI: 10.1200/jco.2023.41.6_suppl.333.Peer-Reviewed Original ResearchActive surveillanceProstate cancerGene expression testGenomic testingCancer riskPatient experienceGleason Grade Group 1Risk prostate cancerGrade group 1Routine clinical careProstate cancer riskGroup 2 tumorsProstate cancer managementProstate cancer aggressivenessHereditary cancer riskGermline genetic testsTissue-based testsRace/ethnicityInitial biopsyPatient knowledgeMean agePatient counselingCancer managementClinical careExpression test
2018
Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study
Layne TM, Graubard BI, Ma X, Mayne ST, Albanes D. Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study. Prostate Cancer And Prostatic Diseases 2018, 22: 91-100. PMID: 30108373, PMCID: PMC6676904, DOI: 10.1038/s41391-018-0070-9.Peer-Reviewed Original ResearchConceptsProstate cancer riskHazard ratioWhite menAdvanced diseaseBlack raceRisk factorsCancer riskHealth StudyRisk associationDietary vitamin D intakeProstate cancer risk factorsProportional hazards regression modelsBlack menNon-Hispanic white menPositive risk associationVitamin D intakeHistory of diabetesNIH-AARP DietCancer risk factorsProstate cancer screeningHazards regression modelsConfidence intervalsHealth-related factorsCancer risk associationsRace-specific associations
2017
Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California
Wang R, Metayer C, Morimoto L, Wiemels JL, Yang J, DeWan AT, Kang A, Ma X. Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California. American Journal Of Epidemiology 2017, 186: 843-856. PMID: 28535175, PMCID: PMC5860074, DOI: 10.1093/aje/kwx160.Peer-Reviewed Original ResearchConceptsRecord linkage studyMaternal ageOdds ratioPediatric cancerParental agePopulation-based record linkage studyCentral nervous system tumorsRisk of lymphomaPopulation-based studyCancer registry dataNervous system tumorsRisk of leukemiaAge group 0Ages 0Pediatric cancer riskOlder paternal ageOlder age groupsTypes of cancerSystem tumorsRegistry dataCancer riskHigh riskGroup 0Birth recordsAge groupsSerum 25‐hydroxyvitamin D, vitamin D binding protein, and prostate cancer risk in black men
Layne TM, Weinstein SJ, Graubard BI, Ma X, Mayne ST, Albanes D. Serum 25‐hydroxyvitamin D, vitamin D binding protein, and prostate cancer risk in black men. Cancer 2017, 123: 2698-2704. PMID: 28369777, PMCID: PMC5498231, DOI: 10.1002/cncr.30634.Peer-Reviewed Original ResearchConceptsProstate cancer riskD binding proteinVitamin D statusCancer riskD statusOdds ratioProstate cancerLow vitamin D statusSerum DBPOvarian Cancer Screening TrialDecreased prostate cancer riskOverall prostate cancerCancer Screening TrialBlack menProstate cancer screeningApparent inverse associationConfidence intervalsVitamin D binding proteinConditional logistic regressionProstate cancer casesNonaggressive diseaseCohort entryCancer screeningBlood drawInverse association
2015
A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution
Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Research 2015, 75: 4884-4894. PMID: 26527286, PMCID: PMC4651745, DOI: 10.1158/0008-5472.can-15-1105.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaLymphoblastic leukemiaCancer riskRisk allelesGeneral cancer riskPancreatic cancer riskGenome-wide association studiesCase-control populationCDKN2A variantsProtective allelesTumor growthClonal expansionChromosome 9p21.3Hispanic childrenMissense polymorphismStrong riskMissense variantsClonal evolutionRiskLeukemiaTumorsAllelic imbalanceEuropean ancestryPolymorphismOrganophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study
Lerro CC, Koutros S, Andreotti G, Friesen MC, Alavanja MC, Blair A, Hoppin JA, Sandler DP, Lubin JH, Ma X, Zhang Y, Freeman L. Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study. Occupational And Environmental Medicine 2015, 72: 736. PMID: 26150671, PMCID: PMC4909328, DOI: 10.1136/oemed-2014-102798.Peer-Reviewed Original ResearchConceptsCancer incidenceRelative riskCancer riskPesticide applicatorsAgricultural Health Study cohortOP useHealth Study cohortAgricultural Health StudyNon-Hodgkin lymphomaReproductive health historyStudy cohortPotential confoundersOvarian cancerThyroid cancerBreast cancerElevated riskEpidemiological studiesHealth StudyHealth historyPoisson regressionMale populationCancerFurther evaluationDemographic informationSpecific organophosphatesUse of acetochlor and cancer incidence in the Agricultural Health Study
Lerro CC, Koutros S, Andreotti G, Hines CJ, Blair A, Lubin J, Ma X, Zhang Y, Beane Freeman L. Use of acetochlor and cancer incidence in the Agricultural Health Study. International Journal Of Cancer 2015, 137: 1167-1175. PMID: 25559664, PMCID: PMC4492894, DOI: 10.1002/ijc.29416.Peer-Reviewed Original ResearchConceptsAgricultural Health StudyLung cancerPancreatic cancerCancer incidenceRelative riskHealth StudyColorectal cancer riskExposure-response trendsAdditional potential confoundersRisk of melanomaTime of interviewIncident cancerColorectal cancerPotential confoundersEpidemiologic studiesCancer riskPoisson regressionCancerTelephone interviewsPesticide applicatorsDefinitive conclusionsConfidence intervalsRiskMelanomaIncidence
2014
A New Estimation Approach for Combining Epidemiological Data From Multiple Sources
Huang H, Ma X, Waagepetersen R, Holford TR, Wang R, Risch H, Mueller L, Guan Y. A New Estimation Approach for Combining Epidemiological Data From Multiple Sources. Journal Of The American Statistical Association 2014, 109: 11-23. PMID: 24683281, PMCID: PMC3964681, DOI: 10.1080/01621459.2013.870904.Peer-Reviewed Original ResearchEpidemiological dataPopulation-based case-control studyBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemConnecticut Tumor RegistryCase-control studyPancreatic cancer riskGroup of controlsGroup of casesTumor RegistryRisk factorsHealth SurveyCancer riskCertain diseasesSurveillance system
2012
Methyl bromide exposure and cancer risk in the Agricultural Health Study
Barry KH, Koutros S, Lubin JH, Coble JB, Barone-Adesi F, Beane Freeman LE, Sandler DP, Hoppin JA, Ma X, Zheng T, Alavanja MC. Methyl bromide exposure and cancer risk in the Agricultural Health Study. Cancer Causes & Control 2012, 23: 807-818. PMID: 22527160, PMCID: PMC3430844, DOI: 10.1007/s10552-012-9949-2.Peer-Reviewed Original ResearchConceptsStomach cancer riskMethyl bromide exposureCancer riskProstate cancerFamily historySignificant exposure-dependent increaseNonsignificant elevated riskRate ratioAgricultural Health StudyConfidence intervalsExposure-dependent increaseResultsA totalCommon cancerLifetime daysElevated riskHealth StudyPoisson regressionIntensity scoresCancerHuman carcinogenicityPesticide applicatorsHealth effectsStatistical significanceConclusionsOur resultsHuman health effects
2011
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk
Barry KH, Koutros S, Andreotti G, Sandler DP, Burdette LA, Yeager M, Freeman L, Lubin JH, Ma X, Zheng T, Alavanja MC, Berndt SI. Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk. Carcinogenesis 2011, 33: 331-337. PMID: 22102698, PMCID: PMC3271261, DOI: 10.1093/carcin/bgr258.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide exposurePesticide applicatorsPesticide manufacturing workersCase-control studyInteraction p valueProstate cancer casesNucleotide excision repair pathway genesWild-type TT genotypeLogistic regression modelsHuman biomonitoring studiesCancer casesLifetime daysTT genotypeERCC1 rs2298881Male controlsFalse discovery rate methodIntensity scoresSignificant associationNucleotide excision repair pathwayGenotype groupsManufacturing workersUnderlying mechanismGenetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
Barry KH, Koutros S, Berndt SI, Andreotti G, Hoppin JA, Sandler DP, Burdette LA, Yeager M, Freeman LE, Lubin JH, Ma X, Zheng T, Alavanja MC. Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk. Environmental Health Perspectives 2011, 119: 1726-1732. PMID: 21810555, PMCID: PMC3261977, DOI: 10.1289/ehp.1103454.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide applicatorsCT/TT genotypesPesticide manufacturing workersCase-control studyProstate cancer casesLogistic regression modelsTag single nucleotide polymorphismsBase excision repair pathway genesProstate cancerCancer casesFamily historyOxidative DNA damageTT genotypeCC genotypeMale controlsExposure variablesPesticide exposureBase excision repairManufacturing workersUnderlying mechanismRiskBER genes
2009
Energy Intake and Risk of Postmenopausal Breast Cancer: An Expanded Analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort
Sue LY, Schairer C, Ma X, Williams C, Chang SC, Miller AB, McCarty CA, Willcox BJ, Ziegler RG. Energy Intake and Risk of Postmenopausal Breast Cancer: An Expanded Analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 2842-2850. PMID: 19843674, PMCID: PMC2783562, DOI: 10.1158/1055-9965.epi-09-0087.Peer-Reviewed Original ResearchConceptsFood frequency questionnaireOvarian Cancer Screening Trial (PLCO) cohortPostmenopausal breast cancerBreast cancerEnergy intakeTrial cohortDietary assessmentIncident breast cancerBody mass indexBreast cancer riskFirst food frequency questionnaireLower energy intakeModest positive associationMultivariate RRsFrequency questionnaireHighest quartileMass indexLowest quartilePhysical activitySimilar riskCancer riskHuman studiesAge 55CancerAnimal experimentsXenobiotic Metabolizing Gene Variants, Dietary Heterocyclic Amine Intake, and Risk of Prostate Cancer
Koutros S, Berndt SI, Sinha R, Ma X, Chatterjee N, Alavanja MC, Zheng T, Huang WY, Hayes RB, Cross AJ. Xenobiotic Metabolizing Gene Variants, Dietary Heterocyclic Amine Intake, and Risk of Prostate Cancer. Cancer Research 2009, 69: 1877-1884. PMID: 19223546, PMCID: PMC2662592, DOI: 10.1158/0008-5472.can-08-2447.Peer-Reviewed Original ResearchConceptsProstate cancer riskProstate cancerOdds ratioCancer riskSingle nucleotide polymorphismsDietary Heterocyclic Amine IntakeOvarian Cancer Screening TrialHeterocyclic amine intakeCancer Screening TrialUnconditional logistic regressionCase-control studyDietary heterocyclic aminesProstate cancer casesHeterocyclic aminesHCA intakeCancer casesLow intakeScreening TrialHCA metabolismMalignant transformationLogistic regressionCancerIntakeGene variantsConfidence intervals
2008
Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study
Koutros S, Lynch CF, Ma X, Lee WJ, Hoppin JA, Christensen CH, Andreotti G, Freeman LB, Rusiecki JA, Hou L, Sandler DP, Alavanja MC. Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study. International Journal Of Cancer 2008, 124: 1206-1212. PMID: 19058219, PMCID: PMC2904521, DOI: 10.1002/ijc.24020.Peer-Reviewed Original ResearchConceptsAgricultural Health StudyColon cancerPesticide applicatorsBladder cancerCancer incidenceHealth StudyIntensity-weighted lifetime exposure daysEtiology of bladderLifetime exposure daysRate ratioLicensed pesticide applicatorsPoisson regression analysisHuman cancer riskProximal cancersIncident cancerProspective cohortLymphohematopoietic cancersExcess riskCancer riskExposure daysLifetime exposureCancerRegression analysisRiskHeterocyclic aromatic amines
2007
Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study
Koutros S, Mahajan R, Zheng T, Hoppin JA, Ma X, Lynch CF, Blair A, Alavanja MC. Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study. Cancer Causes & Control 2007, 19: 59-65. PMID: 17943454, PMCID: PMC2822646, DOI: 10.1007/s10552-007-9070-0.Peer-Reviewed Original ResearchConceptsDDVP exposurePesticide applicatorsRate ratioAgricultural Health Study cohortCumulative exposure daysHealth Study cohortSmall excess riskConfidence intervalsLicensed pesticide applicatorsPoisson regression analysisLymphohematopoietic cancersStudy cohortIncident casesPotential confoundersExcess riskProstate cancerFamily historyCancer riskExposure daysCancerComprehensive questionnaireRegression analysisCohortExposureRisk