2023
One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns
Metayer C, Imani P, Dudoit S, Morimoto L, Ma X, Wiemels J, Petrick L. One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns. Cancers 2023, 15: 1011. PMID: 36831356, PMCID: PMC9953980, DOI: 10.3390/cancers15041011.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaOne-carbon metabolism nutrientsRace/ethnicityLymphoblastic leukemiaFolic acid intakeTime of conceptionOne-carbon metabolism pathwaySubsequent leukemiaFirst trimesterAcid intakeCommon cancerDNA methylation programmingChildhood leukemiaLeukemiaNegative findingsBlood spotsBiomarker studiesPathway metabolitesFolic acidAges 0Key vitaminsPregnancyLast weekFolate pathway
2022
Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOddsInteraction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL
Feng Q, Zhou M, Li S, Morimoto L, Hansen H, Myint SS, Wang R, Metayer C, Kang A, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL. Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL. Blood Advances 2022, 6: 3756-3766. PMID: 35500222, PMCID: PMC9631572, DOI: 10.1182/bloodadvances.2021006821.Peer-Reviewed Original ResearchConceptsKiller immunoglobulin-like receptorsMaternal killer immunoglobulin-like receptorsAcute lymphoblastic leukemiaChild-mother pairsImmunoglobulin-like receptorsArginase IIKIR interactionsLower riskNon-Latino white subjectsLower tumor necrosisCase-control studyEtiology of childhoodDevelopment of childhoodHLA-KIRNeonatal cytokinesCytokine levelsCytokine profileLymphoblastic leukemiaImmune factorsImmune phenotypeTumor necrosisHigh riskChildhood leukemiaCytokine controlSignificant association
2016
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence
Elliott EG, Trinh P, Ma X, Leaderer BP, Ward MH, Deziel NC. Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. The Science Of The Total Environment 2016, 576: 138-147. PMID: 27783932, PMCID: PMC6457992, DOI: 10.1016/j.scitotenv.2016.10.072.Peer-Reviewed Original ResearchConceptsWater contaminantsPotential water contaminantsMajority of compoundsWater pollutantsPolycyclic aromatic hydrocarbonsHydraulic fracturing fluidsPollutantsAromatic hydrocarbonsAir pollutantsU.S. Environmental Protection AgencyCompoundsEnvironmental Protection AgencyPotential air pollutantsPossible human carcinogenContaminantsChemicalsCarcinogenicity of compoundsLeukemia/lymphomaProtection AgencyChildhood leukemiaWaterButadieneBenzeneFracturing fluidOilAir toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study
Symanski E, Tee Lewis PG, Chen TY, Chan W, Lai D, Ma X. Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. Environmental Health 2016, 15: 70. PMID: 27301866, PMCID: PMC4908700, DOI: 10.1186/s12940-016-0154-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsBenzeneButadienesCase-Control StudiesChild, PreschoolEnvironmental MonitoringFemaleHumansInfantInfant, NewbornMaleMaternal ExposureOdds RatioPolycyclic Aromatic HydrocarbonsPrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPrenatal Exposure Delayed EffectsTexasYoung AdultConceptsAcute lymphocytic leukemiaCo-pollutant modelsCase-control studySingle-pollutant modelsChildhood leukemiaLymphocytic leukemiaChildhood acute lymphocytic leukemiaBirth certificatesCancer registry casesPopulation-based controlsEarly life exposureMixed effects logistic regression modelsEarly childhood risksLogistic regression modelsPotential confoundersEtiologic roleLowest quartileRegistry casesInfant characteristicsLife exposurePediatric cancerMaternal addressControl studyBirth recordsLeukemia
2010
A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia
Urayama KY, Buffler PA, Gallagher ER, Ayoob JM, Ma X. A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia. International Journal Of Epidemiology 2010, 39: 718-732. PMID: 20110276, PMCID: PMC2878455, DOI: 10.1093/ije/dyp378.Peer-Reviewed Original ResearchConceptsDay care attendanceAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaLymphoblastic leukemiaOdds ratioRisk of childhoodCase-control studyEarly life exposureRandom-effects modelCommon infectionsSubgroup analysisProphylactic interventionsInfluence of timingObservational studyChildhood leukemiaStudy heterogeneityPubMed databaseInfected individualsRisk estimatesSimilar findingsLeukemiaInfectionEarly childhoodRare responsesEffects model
2008
Exposure to infections through day-care attendance and risk of childhood leukaemia
Urayama KY, Ma X, Buffler PA. Exposure to infections through day-care attendance and risk of childhood leukaemia. Radiation Protection Dosimetry 2008, 132: 259-266. PMID: 18940822, PMCID: PMC2879097, DOI: 10.1093/rpd/ncn271.Peer-Reviewed Original ResearchConceptsDay care attendanceRisk of childhoodAcute lymphoblastic leukemiaChildhood leukemiaCommon infectionsMore common infectionsNon-Hispanic white childrenNorthern California Childhood Leukemia StudyCommon B-cell precursorDose-response effectPrevious epidemiological studiesCalifornia Childhood Leukemia StudyChildhood Leukemia StudyB cell precursorsDay care settingsSummary measuresLymphoblastic leukemiaEpidemiological studiesNumber of childrenMajority of studiesInfectionLeukemiaLeukemia StudySocial contactRelevant studies
2006
Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California
Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 578-581. PMID: 16537719, DOI: 10.1158/1055-9965.epi-05-0833.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionCaliforniaChildChild, PreschoolCohort StudiesCore Binding Factor Alpha 2 SubunitCytogeneticsFemaleGene Expression Regulation, NeoplasticGenetic MarkersGenetic Predisposition to DiseaseHispanic or LatinoHumansIn Situ Hybridization, FluorescenceIncidenceInfantMaleOncogene Proteins, FusionPloidiesPrecursor Cell Lymphoblastic Leukemia-LymphomaProbabilityProspective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSex DistributionSurvival RateWhite PeopleConceptsAcute lymphoblastic leukemia patientsNon-Hispanic whitesLymphoblastic leukemia patientsLeukemia patientsB-lineage acute lymphoblastic leukemia patientsNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood leukemia patientsEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsLymphoblastic leukemiaRisk factorsEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profilePatientsMLL rearrangementsLeukemia Study
2005
Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California.
Aldrich M, Zhang L, Wiemels J, Ma X, Loh M, Selvin S, Feusner J, Smith M, Buffler P. Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California. Blood 2005, 106: 4536. DOI: 10.1182/blood.v106.11.4536.4536.Peer-Reviewed Original ResearchNon-Hispanic whitesChildhood leukemia patientsRisk factorsLeukemia patientsMLL rearrangementsChildhood acute lymphoblastic leukemiaNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyFirst large studyEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsCytogenetic characteristicsHeterogeneity of leukemiaLymphoblastic leukemiaEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profileDistinct etiologiesMaternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States)
Ma X, Metayer C, Does MB, Buffler PA. Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States). Cancer Causes & Control 2005, 16: 1075-1083. PMID: 16184473, DOI: 10.1007/s10552-005-0356-9.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdolescentBirth CertificatesBirth IntervalsBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornLeukemia, Myeloid, AcuteMalePrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPregnancy, High-RiskRisk AssessmentRisk FactorsConceptsBirth characteristicsPregnancy lossChildhood leukemiaOdds ratioNorthern California Childhood Leukemia StudyHistory of miscarriageConfidence intervalsRisk of AMLConditional logistic regressionDetailed reproductive historyCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood AMLIncident casesBirth weightMaternal historyIndex childReproductive historyBirth recordsLogistic regressionRecall biasBirth certificatesLeukemia StudyAMLLeukemiaMolecular biomarkers for the study of childhood leukemia
Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. Molecular biomarkers for the study of childhood leukemia. Toxicology And Applied Pharmacology 2005, 206: 237-245. PMID: 15967214, DOI: 10.1016/j.taap.2004.11.026.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute lymphocytic leukemiaChildhood leukemiaLeukemia riskChildhood acute lymphocytic leukemiaC609T polymorphismLow folate intakeNeonatal blood spotsYears of lifeMethylenetetrahydrofolate reductase (MTHFR) geneDifferent cytogenetic subgroupsPerinatal exposureFolate intakeMyeloid leukemiaLymphocytic leukemiaT polymorphismUseful biomarkerInfectious agentsAberrant gene methylationLeukemiaCytogenetic subgroupsBlood spotsMolecular biomarkersIndoor pesticidesGene methylationVaccination history and risk of childhood leukaemia
Ma X, Does MB, Metayer C, Russo C, Wong A, Buffler PA. Vaccination history and risk of childhood leukaemia. International Journal Of Epidemiology 2005, 34: 1100-1109. PMID: 15951359, DOI: 10.1093/ije/dyi113.Peer-Reviewed Original ResearchConceptsChildhood leukemiaB vaccineHaemophilus influenzae type b vaccineInfluenzae type b vaccineConditional logistic regression analysisBirth certificate controlsType b vaccineHepatitis B vaccineNorthern California Childhood Leukemia StudyCase-control studyRole of vaccinationNumber of dosesType of vaccineRisk of leukemiaPotential confounding factorsLogistic regression analysisCalifornia Childhood Leukemia StudyChildhood Leukemia StudyDetailed exposure assessmentNumber of administrationsHib vaccinationHib vaccineVaccination historyIncident casesMore dosesRAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 2005, 19: 415-419. PMID: 15674422, DOI: 10.1038/sj.leu.2403641.Peer-Reviewed Original ResearchConceptsRAS mutationsMaternal ageLeukemia casesPediatric acute lymphoblastic leukemiaAcute lymphoblastic leukemia casesDiagnostic bone marrow samplesIncident leukemia casesPaternal preconception smokingNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaLymphoblastic leukemia casesBone marrow samplesKRAS codon 12California Childhood Leukemia StudyRAS gene mutationsChildhood Leukemia StudyEtiology of subtypesPreconception smokingCase seriesLymphoblastic leukemiaLeukemia patientsMultivariable modelMarrow samplesHigh hyperdiploidyChildhood leukemia
2002
Critical windows of exposure to household pesticides and risk of childhood leukemia.
Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental Health Perspectives 2002, 110: 955-960. PMID: 12204832, PMCID: PMC1240997, DOI: 10.1289/ehp.02110955.Peer-Reviewed Original ResearchConceptsHigh riskChildhood leukemiaNorthern California Childhood Leukemia StudyPotential etiologic roleCalifornia Childhood Leukemia StudyHousehold pesticidesLocation of exposureChildhood Leukemia StudyHousehold pesticide exposureBirth RegistryControl subjectsEtiologic roleElevated riskSignificant associationLeukemiaPregnancyCritical windowLeukemia StudyLate exposureFrequent exposurePesticide exposureRiskExposureYear 2Year 1
2001
Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations.
Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 697-700. PMID: 11401921.Peer-Reviewed Original ResearchConceptsPediatric populationBuccal cellsNurse-administered protocolGlutathione S-transferase muPediatric acute leukemiaMethylenetetrahydrofolate reductase (MTHFR) polymorphismsPeripheral whole bloodGlutathione S-transferase thetaAcute leukemiaCytology brushWhole genome amplificationChildhood leukemiaBone marrowBuccal cell DNANoninvasive methodWhole bloodRepeat testsSuccess rateGenome amplificationOngoing studiesBuccal samplesLeukemiaBloodBuccal DNACell DNA