2012
Methyl bromide exposure and cancer risk in the Agricultural Health Study
Barry KH, Koutros S, Lubin JH, Coble JB, Barone-Adesi F, Beane Freeman LE, Sandler DP, Hoppin JA, Ma X, Zheng T, Alavanja MC. Methyl bromide exposure and cancer risk in the Agricultural Health Study. Cancer Causes & Control 2012, 23: 807-818. PMID: 22527160, PMCID: PMC3430844, DOI: 10.1007/s10552-012-9949-2.Peer-Reviewed Original ResearchConceptsStomach cancer riskMethyl bromide exposureCancer riskProstate cancerFamily historySignificant exposure-dependent increaseNonsignificant elevated riskRate ratioAgricultural Health StudyConfidence intervalsExposure-dependent increaseResultsA totalCommon cancerLifetime daysElevated riskHealth StudyPoisson regressionIntensity scoresCancerHuman carcinogenicityPesticide applicatorsHealth effectsStatistical significanceConclusionsOur resultsHuman health effects
2011
Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
Barry KH, Koutros S, Berndt SI, Andreotti G, Hoppin JA, Sandler DP, Burdette LA, Yeager M, Freeman LE, Lubin JH, Ma X, Zheng T, Alavanja MC. Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk. Environmental Health Perspectives 2011, 119: 1726-1732. PMID: 21810555, PMCID: PMC3261977, DOI: 10.1289/ehp.1103454.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide applicatorsCT/TT genotypesPesticide manufacturing workersCase-control studyProstate cancer casesLogistic regression modelsTag single nucleotide polymorphismsBase excision repair pathway genesProstate cancerCancer casesFamily historyOxidative DNA damageTT genotypeCC genotypeMale controlsExposure variablesPesticide exposureBase excision repairManufacturing workersUnderlying mechanismRiskBER genes
2008
Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study
Koutros S, Cross AJ, Sandler DP, Hoppin JA, Ma X, Zheng T, Alavanja MC, Sinha R. Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 80-87. PMID: 18199713, PMCID: PMC2935655, DOI: 10.1158/1055-9965.epi-07-0392.Peer-Reviewed Original ResearchConceptsAgricultural Health StudyProstate cancerHealth StudyMeat mutagensIncident prostate cancer casesCox proportional hazards regressionComplete dietary dataUnderlying time metricIncident prostate cancerProportional hazards regressionMeat cooking methodsProstate cancer riskProstate cancer casesCarcinogenic heterocyclic aminesAdvanced diseaseHighest tertileSmoking statusHazards regressionBorderline significanceHighest quintileIncident diseaseRelative riskCancer casesFamily historyState of residence
2007
Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study
Koutros S, Mahajan R, Zheng T, Hoppin JA, Ma X, Lynch CF, Blair A, Alavanja MC. Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study. Cancer Causes & Control 2007, 19: 59-65. PMID: 17943454, PMCID: PMC2822646, DOI: 10.1007/s10552-007-9070-0.Peer-Reviewed Original ResearchConceptsDDVP exposurePesticide applicatorsRate ratioAgricultural Health Study cohortCumulative exposure daysHealth Study cohortSmall excess riskConfidence intervalsLicensed pesticide applicatorsPoisson regression analysisLymphohematopoietic cancersStudy cohortIncident casesPotential confoundersExcess riskProstate cancerFamily historyCancer riskExposure daysCancerComprehensive questionnaireRegression analysisCohortExposureRisk