2024
Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium
Metayer C, Spector L, Scheurer M, Jeon S, Scott R, Takagi M, Clavel J, Manabe A, Ma X, Hailu E, Lupo P, Urayama K, Bonaventure A, Kato M, Meirhaeghe A, Chiang C, Morimoto L, Wiemels J. Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 1248-1252. PMID: 38904462, PMCID: PMC11369612, DOI: 10.1158/1055-9965.epi-24-0189.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsGenome-wide dataAncestry groupsFolate metabolic pathwayGenetic variantsChildhood cancerMetabolic pathwaysGenetic pathway analysisRisk of childhood ALLRisk of childhood acute lymphoblastic leukemiaGene-folate interactionsChildhood ALL riskCase-control studyDNA methylationMETAL softwareGenetic studiesNucleotide polymorphismsPathway analysisMeta-analysis of original dataALL riskGenetic effectsAncestryFolate pathwayMaternal genetic effectsFolate intake
2023
One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns
Metayer C, Imani P, Dudoit S, Morimoto L, Ma X, Wiemels J, Petrick L. One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns. Cancers 2023, 15: 1011. PMID: 36831356, PMCID: PMC9953980, DOI: 10.3390/cancers15041011.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaOne-carbon metabolism nutrientsRace/ethnicityLymphoblastic leukemiaFolic acid intakeTime of conceptionOne-carbon metabolism pathwaySubsequent leukemiaFirst trimesterAcid intakeCommon cancerDNA methylation programmingChildhood leukemiaLeukemiaNegative findingsBlood spotsBiomarker studiesPathway metabolitesFolic acidAges 0Key vitaminsPregnancyLast weekFolate pathway