2018
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium
Petridou ET, Georgakis MK, Erdmann F, Ma X, Heck JE, Auvinen A, Mueller BA, Spector LG, Roman E, Metayer C, Magnani C, Pombo-de-Oliveira MS, Ezzat S, Scheurer ME, Mora AM, Dockerty JD, Hansen J, Kang AY, Wang R, Doody DR, Kane E, Rashed WM, Dessypris N, Schüz J, Infante-Rivard C, Skalkidou A. Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. European Journal Of Epidemiology 2018, 33: 965-976. PMID: 29761423, PMCID: PMC6384148, DOI: 10.1007/s10654-018-0402-z.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood Leukemia International ConsortiumChildhood acute lymphoblastic leukemiaCase-control studyAdvanced parental ageLymphoblastic leukemiaOdds ratioParental agePaternal ageAdvanced maternal ageSimilar positive associationPositive associationAdverse health effectsMaternal ageRisk factorsEnrollment periodStudy designAge incrementsHealth effectsFive yearsAgeUnderlying mechanismInternational ConsortiumLeukemiaRisk
2012
Methyl bromide exposure and cancer risk in the Agricultural Health Study
Barry KH, Koutros S, Lubin JH, Coble JB, Barone-Adesi F, Beane Freeman LE, Sandler DP, Hoppin JA, Ma X, Zheng T, Alavanja MC. Methyl bromide exposure and cancer risk in the Agricultural Health Study. Cancer Causes & Control 2012, 23: 807-818. PMID: 22527160, PMCID: PMC3430844, DOI: 10.1007/s10552-012-9949-2.Peer-Reviewed Original ResearchConceptsStomach cancer riskMethyl bromide exposureCancer riskProstate cancerFamily historySignificant exposure-dependent increaseNonsignificant elevated riskRate ratioAgricultural Health StudyConfidence intervalsExposure-dependent increaseResultsA totalCommon cancerLifetime daysElevated riskHealth StudyPoisson regressionIntensity scoresCancerHuman carcinogenicityPesticide applicatorsHealth effectsStatistical significanceConclusionsOur resultsHuman health effects