2005
Molecular biomarkers for the study of childhood leukemia
Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. Molecular biomarkers for the study of childhood leukemia. Toxicology And Applied Pharmacology 2005, 206: 237-245. PMID: 15967214, DOI: 10.1016/j.taap.2004.11.026.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute lymphocytic leukemiaChildhood leukemiaLeukemia riskChildhood acute lymphocytic leukemiaC609T polymorphismLow folate intakeNeonatal blood spotsYears of lifeMethylenetetrahydrofolate reductase (MTHFR) geneDifferent cytogenetic subgroupsPerinatal exposureFolate intakeMyeloid leukemiaLymphocytic leukemiaT polymorphismUseful biomarkerInfectious agentsAberrant gene methylationLeukemiaCytogenetic subgroupsBlood spotsMolecular biomarkersIndoor pesticidesGene methylation
2003
Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California
McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes And Cancer 2003, 37: 36-43. PMID: 12661004, DOI: 10.1002/gcc.10199.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCommon acute lymphoblastic leukemiaLymphoblastic leukemiaTEL-AML1CALL patientsPrenatal originTEL-AML1 gene fusionGuthrie cardsPositive acute lymphoblastic leukemiaSecondary changesTime of diagnosisTEL-AML1 fusionNeonatal Guthrie cardsNeonatal blood spotsClonotypic primersClonotypic sequencesOlder patientsPeak incidenceChildhood cancerRetrospective analysisTEL alleleTrisomy 21Blood spotsLeukemiaPatients
2002
Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 15101-15106. PMID: 12415113, PMCID: PMC137550, DOI: 10.1073/pnas.222481199.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentArtificial Gene FusionBase SequenceChildChild, PreschoolChromosome MappingChromosomes, Human, Pair 1Chromosomes, Human, Pair 19FemaleGene RearrangementHomeodomain ProteinsHumansImmunoglobulin Heavy ChainsInfantMaleMolecular Sequence DataOncogene Proteins, FusionPolymerase Chain ReactionPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Antigen, T-CellRestriction MappingTranslocation, GeneticConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaTime of birthChildhood acute lymphoblastic leukemiaE2A-PBX1 fusionSubtype of leukemiaAntigen receptor rearrangementNeonatal blood spotsIg heavy chainPediatric patientsTCR rearrangementsPrenatal originReceptor rearrangementPostnatal originCell originMolecular subgroupsLeukemiaNatural historyBlood spotsGuthrie cardsPatientsCell linesChromosomal translocationsPBX1 geneGenomic fusion