2024
Racial differences in treatment and survival among older patients with multiple myeloma
Wang R, Neparidze N, Ma X, Colditz G, Chang S, Wang S. Racial differences in treatment and survival among older patients with multiple myeloma. Cancer Medicine 2024, 13: e6915. PMID: 38234237, PMCID: PMC10905251, DOI: 10.1002/cam4.6915.Peer-Reviewed Original ResearchNon-Hispanic whitesNon-Hispanic white patientsMultiple myelomaRacial differencesHazard ratioReceipt of treatmentOlder patientsIncreasing racial disparitiesIntroduction of novel agentsCox proportional hazards modelsMultivariate Cox proportional hazards modelLower mortalityStudy investigated racial differencesAssess survival outcomesProportional hazards modelNon-HispanicProportion of patientsMedicare beneficiariesRacial disparitiesTreatment utilizationHazards modelSurvival outcomesNovel agentsMM survivalMM treatment
2023
Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001–2015
Cote D, Wang R, Morimoto L, Metayer C, Zada G, Wiemels J, Ma X. Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001–2015. Cancer Causes & Control 2023, 34: 757-768. PMID: 37225897, PMCID: PMC10363066, DOI: 10.1007/s10552-023-01718-7.Peer-Reviewed Original ResearchConceptsOlder maternal ageMultivariable logistic regressionNon-Hispanic white individualsHigher maternal educationPituitary adenomasBirth characteristicsMaternal educationSignificant associationMaternal ageOdds ratioNon-Hispanic white raceUnconditional multivariable logistic regressionLogistic regressionParental sociodemographic characteristicsRegistry-based studyPopulation-based studyWhite individualsAdjusted odds ratioEarly-onset cancersNon-Hispanic whitesBirth pluralityIncident casesBlack raceFemale sexHispanic ethnicity
2022
Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case–Control Study
Graham C, Metayer C, Morimoto LM, Wiemels JL, Siddique A, Di M, Rodwin RL, Kadan-Lottick NS, Ma X, Wang R. Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case–Control Study. Cancer Epidemiology Biomarkers & Prevention 2022, 31: 1788-1795. PMID: 35709749, PMCID: PMC9444874, DOI: 10.1158/1055-9965.epi-22-0335.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesHodgkin's lymphomaCase-control studyBirth characteristicsMaternal birthplaceMaternal agePopulation-based case-control studyMultivariable logistic regression modelConfidence intervalsEthnic differencesEarly-onset cancersPotential ethnic differencesForeign-born mothersLogistic regression modelsEthnicity differencesRace/ethnicityYear of birthLymphomaPaternal ageFemale HispanicsHispanic casesMale HispanicsHodgkinAgeRisk
2020
Birth Characteristics and Risk of Early-Onset Synovial Sarcoma
Wiemels JL, Wang R, Feng Q, Clark CJ, Amatruda JF, Rubin E, Yee AC, Morimoto LM, Metayer C, Ma X. Birth Characteristics and Risk of Early-Onset Synovial Sarcoma. Cancer Epidemiology Biomarkers & Prevention 2020, 29: 1162-1167. PMID: 32245786, PMCID: PMC7605594, DOI: 10.1158/1055-9965.epi-20-0093.Peer-Reviewed Original ResearchConceptsSynovial sarcomaBirth weightMultivariable logistic regression analysisEpidemiologic researchFurther epidemiologic researchLittle epidemiologic researchHigh birth weightSynovial sarcoma casesSiblings of patientsLogistic regression analysisBirth orderNon-Hispanic whitesYoung adult periodYear of birthElevated cancer incidencePoor outcomeBirth characteristicsPeak incidenceRare cancersRisk factorsCancer incidenceCancer casesAggressive cancerHigh riskSarcoma cases
2016
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood 2016, 129: 1680-1684. PMID: 27979823, PMCID: PMC5364339, DOI: 10.1182/blood-2016-07-723148.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCMV infectionCytomegalovirus infectionLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaUtero cytomegalovirus infectionCongenital CMV infectionCommon childhood cancerActive viral transcriptionBone marrow specimensNon-Hispanic whitesTiming of infectionNewborn blood samplesEtiologic roleRisk factorsChildhood cancerHealthy controlsHigh prevalenceMarrow specimensLeukemia blastsBlood samplesPrenatal originEtiologic agentInfectionHispanic children
2015
Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California
Morimoto LM, McCauley K, Ma X, Wiemels JL, Chokkalingam AP, Metayer C. Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Annals Of Epidemiology 2015, 26: 141-145. PMID: 26795698, DOI: 10.1016/j.annepidem.2015.11.007.Peer-Reviewed Original ResearchConceptsRisk of rhabdomyosarcomaHigh birth weightBirth weightGestational ageNon-Hispanic white childrenPost-term babiesCalifornia Cancer RegistryNormal gestational ageRecord linkage studyConditional logistic regressionCalifornia birth recordsNon-Hispanic whitesIndication of associationCancer RegistryBirth characteristicsFetal growthPediatric rhabdomyosarcomaRMS casesLower riskBirth recordsEthnic groupsLarger studyLogistic regressionWhite childrenAge
2012
HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk
Urayama KY, Chokkalingam AP, Metayer C, Ma X, Selvin S, Barcellos LF, Wiemels JL, Wiencke JK, Taylor M, Brennan P, Dahl GV, Moonsamy P, Erlich HA, Trachtenberg E, Buffler PA. HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk. Blood 2012, 120: 3039-3047. PMID: 22923493, PMCID: PMC3471514, DOI: 10.1182/blood-2012-01-404723.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCase-Control StudiesChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHispanic or LatinoHLA-DP alpha-ChainsHLA-DP beta-ChainsHumansImmunologic FactorsInfantMalePrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisRisk FactorsWhite PeopleYoung AdultConceptsAcute lymphoblastic leukemiaImmune modulationChildhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemia riskAcute lymphoblastic leukemia riskEarly immune modulationHuman leukocyte antigen (HLA) genesLowest exposure categoryLogistic regression analysisEtiology of childhoodNon-Hispanic whitesHLA-DPB1 geneRace/ethnicityInfectious exposureLymphoblastic leukemiaImmune mechanismsExposure categoriesHispanic ethnicityLeukemia riskGenetic susceptibility lociHLA-DPA1Immune systemHispanic childrenRegression analysisEvidence of interaction
2006
Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California
Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 578-581. PMID: 16537719, DOI: 10.1158/1055-9965.epi-05-0833.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionCaliforniaChildChild, PreschoolCohort StudiesCore Binding Factor Alpha 2 SubunitCytogeneticsFemaleGene Expression Regulation, NeoplasticGenetic MarkersGenetic Predisposition to DiseaseHispanic or LatinoHumansIn Situ Hybridization, FluorescenceIncidenceInfantMaleOncogene Proteins, FusionPloidiesPrecursor Cell Lymphoblastic Leukemia-LymphomaProbabilityProspective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSex DistributionSurvival RateWhite PeopleConceptsAcute lymphoblastic leukemia patientsNon-Hispanic whitesLymphoblastic leukemia patientsLeukemia patientsB-lineage acute lymphoblastic leukemia patientsNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood leukemia patientsEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsLymphoblastic leukemiaRisk factorsEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profilePatientsMLL rearrangementsLeukemia Study
2005
Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California.
Aldrich M, Zhang L, Wiemels J, Ma X, Loh M, Selvin S, Feusner J, Smith M, Buffler P. Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California. Blood 2005, 106: 4536. DOI: 10.1182/blood.v106.11.4536.4536.Peer-Reviewed Original ResearchNon-Hispanic whitesChildhood leukemia patientsRisk factorsLeukemia patientsMLL rearrangementsChildhood acute lymphoblastic leukemiaNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyFirst large studyEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsCytogenetic characteristicsHeterogeneity of leukemiaLymphoblastic leukemiaEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profileDistinct etiologies