2015
Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study
Lerro CC, Koutros S, Andreotti G, Friesen MC, Alavanja MC, Blair A, Hoppin JA, Sandler DP, Lubin JH, Ma X, Zhang Y, Freeman L. Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study. Occupational And Environmental Medicine 2015, 72: 736. PMID: 26150671, PMCID: PMC4909328, DOI: 10.1136/oemed-2014-102798.Peer-Reviewed Original ResearchConceptsCancer incidenceRelative riskCancer riskPesticide applicatorsAgricultural Health Study cohortOP useHealth Study cohortAgricultural Health StudyNon-Hodgkin lymphomaReproductive health historyStudy cohortPotential confoundersOvarian cancerThyroid cancerBreast cancerElevated riskEpidemiological studiesHealth StudyHealth historyPoisson regressionMale populationCancerFurther evaluationDemographic informationSpecific organophosphatesUse of acetochlor and cancer incidence in the Agricultural Health Study
Lerro CC, Koutros S, Andreotti G, Hines CJ, Blair A, Lubin J, Ma X, Zhang Y, Beane Freeman L. Use of acetochlor and cancer incidence in the Agricultural Health Study. International Journal Of Cancer 2015, 137: 1167-1175. PMID: 25559664, PMCID: PMC4492894, DOI: 10.1002/ijc.29416.Peer-Reviewed Original ResearchConceptsAgricultural Health StudyLung cancerPancreatic cancerCancer incidenceRelative riskHealth StudyColorectal cancer riskExposure-response trendsAdditional potential confoundersRisk of melanomaTime of interviewIncident cancerColorectal cancerPotential confoundersEpidemiologic studiesCancer riskPoisson regressionCancerTelephone interviewsPesticide applicatorsDefinitive conclusionsConfidence intervalsRiskMelanomaIncidence
2012
Methyl bromide exposure and cancer risk in the Agricultural Health Study
Barry KH, Koutros S, Lubin JH, Coble JB, Barone-Adesi F, Beane Freeman LE, Sandler DP, Hoppin JA, Ma X, Zheng T, Alavanja MC. Methyl bromide exposure and cancer risk in the Agricultural Health Study. Cancer Causes & Control 2012, 23: 807-818. PMID: 22527160, PMCID: PMC3430844, DOI: 10.1007/s10552-012-9949-2.Peer-Reviewed Original ResearchConceptsStomach cancer riskMethyl bromide exposureCancer riskProstate cancerFamily historySignificant exposure-dependent increaseNonsignificant elevated riskRate ratioAgricultural Health StudyConfidence intervalsExposure-dependent increaseResultsA totalCommon cancerLifetime daysElevated riskHealth StudyPoisson regressionIntensity scoresCancerHuman carcinogenicityPesticide applicatorsHealth effectsStatistical significanceConclusionsOur resultsHuman health effects
2011
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk
Barry KH, Koutros S, Andreotti G, Sandler DP, Burdette LA, Yeager M, Freeman L, Lubin JH, Ma X, Zheng T, Alavanja MC, Berndt SI. Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk. Carcinogenesis 2011, 33: 331-337. PMID: 22102698, PMCID: PMC3271261, DOI: 10.1093/carcin/bgr258.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide exposurePesticide applicatorsPesticide manufacturing workersCase-control studyInteraction p valueProstate cancer casesNucleotide excision repair pathway genesWild-type TT genotypeLogistic regression modelsHuman biomonitoring studiesCancer casesLifetime daysTT genotypeERCC1 rs2298881Male controlsFalse discovery rate methodIntensity scoresSignificant associationNucleotide excision repair pathwayGenotype groupsManufacturing workersUnderlying mechanismGenetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
Barry KH, Koutros S, Berndt SI, Andreotti G, Hoppin JA, Sandler DP, Burdette LA, Yeager M, Freeman LE, Lubin JH, Ma X, Zheng T, Alavanja MC. Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk. Environmental Health Perspectives 2011, 119: 1726-1732. PMID: 21810555, PMCID: PMC3261977, DOI: 10.1289/ehp.1103454.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide applicatorsCT/TT genotypesPesticide manufacturing workersCase-control studyProstate cancer casesLogistic regression modelsTag single nucleotide polymorphismsBase excision repair pathway genesProstate cancerCancer casesFamily historyOxidative DNA damageTT genotypeCC genotypeMale controlsExposure variablesPesticide exposureBase excision repairManufacturing workersUnderlying mechanismRiskBER genes
2008
Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study
Koutros S, Lynch CF, Ma X, Lee WJ, Hoppin JA, Christensen CH, Andreotti G, Freeman LB, Rusiecki JA, Hou L, Sandler DP, Alavanja MC. Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study. International Journal Of Cancer 2008, 124: 1206-1212. PMID: 19058219, PMCID: PMC2904521, DOI: 10.1002/ijc.24020.Peer-Reviewed Original ResearchConceptsAgricultural Health StudyColon cancerPesticide applicatorsBladder cancerCancer incidenceHealth StudyIntensity-weighted lifetime exposure daysEtiology of bladderLifetime exposure daysRate ratioLicensed pesticide applicatorsPoisson regression analysisHuman cancer riskProximal cancersIncident cancerProspective cohortLymphohematopoietic cancersExcess riskCancer riskExposure daysLifetime exposureCancerRegression analysisRiskHeterocyclic aromatic amines
2007
Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study
Koutros S, Mahajan R, Zheng T, Hoppin JA, Ma X, Lynch CF, Blair A, Alavanja MC. Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study. Cancer Causes & Control 2007, 19: 59-65. PMID: 17943454, PMCID: PMC2822646, DOI: 10.1007/s10552-007-9070-0.Peer-Reviewed Original ResearchConceptsDDVP exposurePesticide applicatorsRate ratioAgricultural Health Study cohortCumulative exposure daysHealth Study cohortSmall excess riskConfidence intervalsLicensed pesticide applicatorsPoisson regression analysisLymphohematopoietic cancersStudy cohortIncident casesPotential confoundersExcess riskProstate cancerFamily historyCancer riskExposure daysCancerComprehensive questionnaireRegression analysisCohortExposureRisk