2022
Accelerated epigenetic aging in newborns with Down syndrome
Xu K, Li S, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Ma X, Metayer C, Mueller BA, Roberts I, Walsh KM, Horvath S, Wiemels JL, de Smith A. Accelerated epigenetic aging in newborns with Down syndrome. Aging Cell 2022, 21: e13652. PMID: 35661546, PMCID: PMC9282838, DOI: 10.1111/acel.13652.Peer-Reviewed Original ResearchConceptsDown syndromeAge accelerationEpigenetic age accelerationGestational age accelerationEarly-onset Alzheimer's diseaseTransient abnormal myelopoiesisPotential confounding factorsEpigenetic agingPremature agingSomatic GATA1 mutationsDS patientsAbnormal myelopoiesisBlood cell proportionsNewbornsAlzheimer's diseaseConfounding factorsBrain tissueCell proportionGATA1 mutationsEndocrine systemBloodTargeted sequencingSomatic mutationsSyndromeDisease
2019
The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies
Wiemels J, Muskens I, Li S, Pandey P, Roy R, Hansen H, Siegmund K, Mueller B, Ma X, Metayer C, de Smith A. The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies. Blood 2019, 134: 2510. DOI: 10.1182/blood-2019-131455.Peer-Reviewed Original ResearchTransient abnormal myelopoiesisNon-DS subjectsDS neonatesDown syndromeTrisomy 21Hematopoietic stem cellsBlood cell proportionsT cellsHigher CD8 T cellsCell proportionEpigenome-wide association studiesMean beta valueNon-DS controlsCD8 T cellsCD4 T cellsLow B cellsAcute lymphoblastic leukemiaAcute megakaryoblastic leukemiaMulti-Ethnic StudyNeonatal DNA methylationEthnicity-stratified analysisSignificant DMRsIllumina Infinium MethylationEPIC arrayChromosome 21Non-Latino whites