2023
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.
Zhong C, Li S, Arroyo K, Morimoto L, de Smith A, Metayer C, Ma X, Kogan S, Gauderman W, Wiemels J. Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1707-1715. PMID: 37773025, DOI: 10.1158/1055-9965.epi-23-0258.Peer-Reviewed Original ResearchConceptsMaternal tobacco exposureAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaTobacco exposureLymphoblastic leukemiaLarge population-based studyPopulation-based studyEffects of tobaccoPrenatal tobacco exposureAryl hydrocarbon receptor repressor geneMode of deliverySelf-reported smokingIndividual-level risk factorsGenetic variantsPolygenetic risk scoresYear of birthAHRR hypomethylationSubsequent childhoodMaternal exposureGestational ageRisk factorsTobacco smokeRisk scoreBiological markersBlood spots
2013
Tobacco Smoke Exposure and the Risk of Childhood Acute Lymphoblastic and Myeloid Leukemias by Cytogenetic Subtype
Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. Tobacco Smoke Exposure and the Risk of Childhood Acute Lymphoblastic and Myeloid Leukemias by Cytogenetic Subtype. Cancer Epidemiology Biomarkers & Prevention 2013, 22: 1600-1611. PMID: 23853208, PMCID: PMC3769478, DOI: 10.1158/1055-9965.epi-13-0350.Peer-Reviewed Original ResearchConceptsChildren's passive smokingPassive smokingAcute lymphoblastic leukemiaTobacco smokeMyeloid leukemiaCytogenetic subtypesChildhood acute lymphoblastic leukemiaCHILDHOOD ACUTE LYMPHOBLASTICPaternal prenatal smokingPostnatal passive smokingTobacco smoke exposureRisk of childhoodMultivariable regression analysisTiming of exposureB cell precursorsHyperdiploid B cellsActive smokingPrenatal smokingTobacco smokingSmoke exposureLymphoblastic leukemiaAcute lymphoblasticAML casesElevated riskSmoking