2023
Statin use, survival and incidence of thrombosis among older patients with polycythemia vera and essential thrombocythemia
Podoltsev N, Wang R, Shallis R, Stempel J, Di M, Neparidze N, Zeidan A, Huntington S, Giri S, Hull S, Gore S, Ma X. Statin use, survival and incidence of thrombosis among older patients with polycythemia vera and essential thrombocythemia. Cancer Medicine 2023, 12: 18889-18900. PMID: 37702132, PMCID: PMC10557879, DOI: 10.1002/cam4.6528.Peer-Reviewed Original ResearchConceptsIncidence of thrombosisPolycythemia veraEssential thrombocythemiaStatin useOlder adultsEnd Results-Medicare databasePopulation-based cohort studyArterial thrombotic eventsSurvival of patientsUse of statinsClaims-based studyRisk of thrombosisCardiovascular morbidityCause mortalityTreatment weighting (IPTW) approachCohort studyOlder patientsOverall survivalThrombotic eventsVenous thrombosisPatient populationPrevious registryStatinsTherapeutic strategiesET subgroupAssociation between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001–2015
Cote D, Wang R, Morimoto L, Metayer C, Zada G, Wiemels J, Ma X. Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001–2015. Cancer Causes & Control 2023, 34: 757-768. PMID: 37225897, PMCID: PMC10363066, DOI: 10.1007/s10552-023-01718-7.Peer-Reviewed Original ResearchConceptsOlder maternal ageMultivariable logistic regressionNon-Hispanic white individualsHigher maternal educationPituitary adenomasBirth characteristicsMaternal educationSignificant associationMaternal ageOdds ratioNon-Hispanic white raceUnconditional multivariable logistic regressionLogistic regressionParental sociodemographic characteristicsRegistry-based studyPopulation-based studyWhite individualsAdjusted odds ratioEarly-onset cancersNon-Hispanic whitesBirth pluralityIncident casesBlack raceFemale sexHispanic ethnicity
2021
Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage I
2020
Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California
Deziel N, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X. Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California. Thyroid 2020, 31: 596-606. PMID: 32912083, PMCID: PMC8195873, DOI: 10.1089/thy.2020.0217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBirth CertificatesBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEducational StatusFemaleHispanic or LatinoHumansIncidenceInfantInfant, NewbornMaleRace FactorsRegistriesRisk AssessmentRisk FactorsSex FactorsThyroid NeoplasmsTime FactorsYoung AdultConceptsPediatric thyroid cancerHigh birth weightFollicular thyroid cancerThyroid cancerHigher birth orderBirth characteristicsRisk factorsHispanic ethnicityBirth weightOdds ratioFirst primary thyroid cancerPapillary thyroid cancer casesBirth orderMultivariable logistic regression modelSecond primary malignanciesLong-term therapyAdjusted odds ratioPopulation-based studyPrimary thyroid cancerRecord linkage studyConfidence intervalsImportant risk factorCancer registry dataCase-control studyThyroid cancer casesEpidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map
Shallis RM, Wang R, Davidoff A, Ma X, Podoltsev NA, Zeidan AM. Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map. Blood Reviews 2020, 42: 100706. PMID: 32517877, DOI: 10.1016/j.blre.2020.100706.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic myeloid leukemiaPolycythemia veraEssential thrombocythemiaMyeloproliferative neoplasmsClassical myeloproliferative neoplasmsPrimary myelofibrosisIncidence of CMLEnd Results program dataTyrosine kinase inhibitor therapyCML patient outcomesClonal myeloid disordersKinase inhibitor therapyPotential etiological roleInhibitor therapyMale genderRisk factorsPatient outcomesMyeloid leukemiaPMF patientsBetter survivalGeneral populationEtiological roleMyeloid disordersMolecular abnormalitiesEpidemiological literatureRisk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case–control study
Shen Y, Risch H, Lu L, Ma X, Irwin ML, Lim JK, Taddei T, Pawlish K, Stroup A, Brown R, Wang Z, Jia W, Wong L, Mayne ST, Yu H. Risk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case–control study. Cancer Causes & Control 2020, 31: 321-332. PMID: 32060838, PMCID: PMC7136513, DOI: 10.1007/s10552-020-01277-1.Peer-Reviewed Original ResearchConceptsRisk of HCCCase-control studyHepatocellular carcinomaRisk factorsHCV infectionHCC riskOdds ratioHepatitis C virus antibodyUnconditional logistic regression modelsElevated HCC riskRapid case ascertainmentC virus antibodyHeavy alcohol intakeConfidence intervalsFamily cancer historyImportant risk factorRandom digit dialingLow socioeconomic statusUnhealthy lifestyle choicesLower household incomeLogistic regression modelsNSAID useAlcohol intakeCigarette smokingHigher BMI
2018
Epidemiology of myelodysplastic syndromes: Why characterizing the beast is a prerequisite to taming it
Zeidan AM, Shallis RM, Wang R, Davidoff A, Ma X. Epidemiology of myelodysplastic syndromes: Why characterizing the beast is a prerequisite to taming it. Blood Reviews 2018, 34: 1-15. PMID: 30314642, DOI: 10.1016/j.blre.2018.09.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCase ascertainmentAllogeneic hematopoietic stem cell transplantationAnnual age-adjusted incidenceHematopoietic stem cell transplantationOutcomes of patientsAge-adjusted incidenceStem cell transplantationAcute myeloid leukemiaTraditional morphologic assessmentClassification of MDSVariable cytopeniasCell transplantationMyelodysplastic syndromePrior receiptInefficient hematopoiesisEffective therapyMale genderRisk factorsMyeloid leukemiaEpidemiological trendsTreatment decisionsMyeloid neoplasmsEpidemiological assessmentDiagnostic criteriaTemporal improvementNeonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT)
Morimoto LM, Zava D, McGlynn KA, Stanczyk FZ, Kang AY, Ma X, Wiemels JL, Metayer C. Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT). Cancer Epidemiology Biomarkers & Prevention 2018, 27: 488-495. PMID: 29475970, PMCID: PMC5884718, DOI: 10.1158/1055-9965.epi-17-0879.Peer-Reviewed Original ResearchConceptsHormone levelsTGCT riskTesticular germ cell tumor incidencePopulation-based case-control studyNon-Hispanic white subjectsAbrupt hormonal changesTumor histologic subtypeCase-control studySex steroid hormonesEarly fetal developmentLogistic regression modelsNeonatal androgensHistologic subtypeNeonatal periodTumor incidenceAndrogen levelsHormone imbalanceHormonal changesFetal developmentAge groupsWhite subjectsSteroid hormonesBlood spotsLiquid chromatography-tandem mass spectrometryTGCT
2017
Risk of myeloid neoplasms after radiotherapy among older women with localized breast cancer: A population-based study
Zeidan AM, Long JB, Wang R, Hu X, Yu JB, Huntington SF, Abel GA, Mougalian SS, Podoltsev NA, Gore SD, Gross CP, Ma X, Davidoff AJ. Risk of myeloid neoplasms after radiotherapy among older women with localized breast cancer: A population-based study. PLOS ONE 2017, 12: e0184747. PMID: 28902882, PMCID: PMC5597231, DOI: 10.1371/journal.pone.0184747.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsMyeloid neoplasmsCancer survivorsBreast cancerOlder womenOlder breast cancer survivorsTherapy-related myeloid neoplasmsCompeting-risks survival analysisAbsolute risk increaseBenefits of radiotherapyPopulation-based studyAbsence of chemotherapyRisk of developmentMultiple sensitivity analysesEligible patientsSubsequent chemotherapyAdjuvant radiotherapyLocalized diseaseCumulative incidenceInitial treatmentSEER registryPoor outcomeTreatment recommendationsMedicare claimsMN diagnosis
2015
Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study
Lerro CC, Koutros S, Andreotti G, Friesen MC, Alavanja MC, Blair A, Hoppin JA, Sandler DP, Lubin JH, Ma X, Zhang Y, Freeman L. Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study. Occupational And Environmental Medicine 2015, 72: 736. PMID: 26150671, PMCID: PMC4909328, DOI: 10.1136/oemed-2014-102798.Peer-Reviewed Original ResearchConceptsCancer incidenceRelative riskCancer riskPesticide applicatorsAgricultural Health Study cohortOP useHealth Study cohortAgricultural Health StudyNon-Hodgkin lymphomaReproductive health historyStudy cohortPotential confoundersOvarian cancerThyroid cancerBreast cancerElevated riskEpidemiological studiesHealth StudyHealth historyPoisson regressionMale populationCancerFurther evaluationDemographic informationSpecific organophosphatesUse of acetochlor and cancer incidence in the Agricultural Health Study
Lerro CC, Koutros S, Andreotti G, Hines CJ, Blair A, Lubin J, Ma X, Zhang Y, Beane Freeman L. Use of acetochlor and cancer incidence in the Agricultural Health Study. International Journal Of Cancer 2015, 137: 1167-1175. PMID: 25559664, PMCID: PMC4492894, DOI: 10.1002/ijc.29416.Peer-Reviewed Original ResearchConceptsAgricultural Health StudyLung cancerPancreatic cancerCancer incidenceRelative riskHealth StudyColorectal cancer riskExposure-response trendsAdditional potential confoundersRisk of melanomaTime of interviewIncident cancerColorectal cancerPotential confoundersEpidemiologic studiesCancer riskPoisson regressionCancerTelephone interviewsPesticide applicatorsDefinitive conclusionsConfidence intervalsRiskMelanomaIncidence
2014
Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B‐cell acute lymphoblastic leukemia
Walsh KM, de Smith A, Welch TC, Smirnov I, Cunningham MJ, Ma X, Chokkalingam AP, Dahl GV, Roberts W, Barcellos LF, Buffler PA, Metayer C, Wiemels JL. Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B‐cell acute lymphoblastic leukemia. American Journal Of Hematology 2014, 89: 721-725. PMID: 24753091, PMCID: PMC4069235, DOI: 10.1002/ajh.23727.Peer-Reviewed Original Research
2013
The Cost of Breast Cancer Screening in the Medicare Population
Gross CP, Long JB, Ross JS, Abu-Khalaf MM, Wang R, Killelea BK, Gold HT, Chagpar AB, Ma X. The Cost of Breast Cancer Screening in the Medicare Population. JAMA Internal Medicine 2013, 173: 220-226. PMID: 23303200, PMCID: PMC3638736, DOI: 10.1001/jamainternmed.2013.1397.Peer-Reviewed Original ResearchConceptsBreast cancer screeningCancer screeningTreatment costsBetter breast cancer outcomesEnd Results-Medicare databaseService MedicareHigh screening costsWomen ages 66Breast cancer outcomesInitial cancer treatmentHospital referral region levelWomen 75 yearsInitial treatment costsEarly-stage cancerDigital screening mammographyCancer outcomesCancer incidenceCancer stageLowest quartileAge 66Breast cancerOlder womenMedicare populationComputer-aided detectionTreatment expenditures
2012
Impact of the 2008 US Preventive Services Task Force Recommendation to Discontinue Prostate Cancer Screening Among Male Medicare Beneficiaries
Ross JS, Wang R, Long JB, Gross CP, Ma X. Impact of the 2008 US Preventive Services Task Force Recommendation to Discontinue Prostate Cancer Screening Among Male Medicare Beneficiaries. JAMA Internal Medicine 2012, 172: 1601-1603. PMID: 22987029, PMCID: PMC3597450, DOI: 10.1001/archinternmed.2012.3726.Peer-Reviewed Original ResearchEpidemiology of Myelodysplastic Syndromes
Ma X. Epidemiology of Myelodysplastic Syndromes. The American Journal Of Medicine 2012, 125: s2-s5. PMID: 22735748, PMCID: PMC3394456, DOI: 10.1016/j.amjmed.2012.04.014.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeIncidence of MDSBetter risk-stratify patientsClonal hematopoietic stem cell malignanciesHematopoietic stem cell malignanciesRisk-stratify patientsStem cell malignanciesMore effective treatmentsMDS prognosisDifferent comorbiditiesPrognostic factorsSignificant morbidityEtiologic factorsDisease burdenPoor survivalEffective treatmentCell malignanciesHigh mortalityNew casesHeterogeneous groupComorbiditiesSyndromeDiseaseRecent studiesPotential interactions
2009
Dietary Meat Intake in Relation to Colorectal Adenoma in Asymptomatic Women
Ferrucci LM, Sinha R, Graubard BI, Mayne ST, Ma X, Schatzkin A, Schoenfeld PS, Cash BD, Flood A, Cross AJ. Dietary Meat Intake in Relation to Colorectal Adenoma in Asymptomatic Women. The American Journal Of Gastroenterology 2009, 104: ajg2009102. PMID: 19367270, PMCID: PMC2891034, DOI: 10.1038/ajg.2009.102.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAdultAgedColonoscopyColorectal NeoplasmsConfidence IntervalsCookingCross-Sectional StudiesDietFemaleFollow-Up StudiesHeterocyclic CompoundsHumansIncidenceLogistic ModelsMass ScreeningMeat ProductsMiddle AgedMultivariate AnalysisOdds RatioReference ValuesRisk AssessmentSeverity of Illness IndexConceptsColorectal adenomasAsymptomatic womenMeat intakeOdds ratioRed meatMeat-cooking methodsColorectal adenoma casesConfidence intervalsPan-fried meatDietary meat intakeEligible womenDoneness levelFood frequencyAdenoma casesHigh intakeAdenomasMeat mutagensLogistic regressionIntakeWomenScreening studyColonoscopyComponents of meatPositive associationFurther investigation
2008
Jakking up tumor registry reporting of the myeloproliferative neoplasms
Selinger HA, Ma X. Jakking up tumor registry reporting of the myeloproliferative neoplasms. American Journal Of Hematology 2008, 84: 124-126. PMID: 19117021, DOI: 10.1002/ajh.21333.Peer-Reviewed Original ResearchExposure to infections through day-care attendance and risk of childhood leukaemia
Urayama KY, Ma X, Buffler PA. Exposure to infections through day-care attendance and risk of childhood leukaemia. Radiation Protection Dosimetry 2008, 132: 259-266. PMID: 18940822, PMCID: PMC2879097, DOI: 10.1093/rpd/ncn271.Peer-Reviewed Original ResearchConceptsDay care attendanceRisk of childhoodAcute lymphoblastic leukemiaChildhood leukemiaCommon infectionsMore common infectionsNon-Hispanic white childrenNorthern California Childhood Leukemia StudyCommon B-cell precursorDose-response effectPrevious epidemiological studiesCalifornia Childhood Leukemia StudyChildhood Leukemia StudyB cell precursorsDay care settingsSummary measuresLymphoblastic leukemiaEpidemiological studiesNumber of childrenMajority of studiesInfectionLeukemiaLeukemia StudySocial contactRelevant studies
2007
Clustering in the incidence of myelodysplastic syndromes
Ma X, Selvin S, Raza A, Foti K, Mayne ST. Clustering in the incidence of myelodysplastic syndromes. Leukemia Research 2007, 31: 1683-1686. PMID: 17507092, DOI: 10.1016/j.leukres.2007.03.032.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisConnecticutDemographyHumansIncidenceMyelodysplastic SyndromesNeoplasmsRegistriesConceptsIncidence of MDSMyelodysplastic syndromePopulation-based cancer registry dataEtiology of MDSPopulation-based dataCancer registry dataGroup of malignanciesPoor prognosisObscure etiologyPotential clusteringRegistry dataHigh incidenceEtiologic hypothesesLarger sample sizeIncidenceSyndromeP-valueEtiologyFuture studiesState of ConnecticutCensus tractsSample sizeIntriguing findingPrognosisMalignancyMyelodysplastic syndromes
Ma X, Does M, Raza A, Mayne ST. Myelodysplastic syndromes. Cancer 2007, 109: 1536-1542. PMID: 17345612, DOI: 10.1002/cncr.22570.Peer-Reviewed Original ResearchConceptsSurvival of patientsOutcome of MDSMyelodysplastic syndromeDescriptive epidemiologic dataHigh incidence rateIncident casesIncidence rateEpidemiologic dataRisk of MDSPopulation-based databaseEnd Results ProgramCancer Reporting SystemPopulation-based cancer reporting systemsPublic-use databaseMDS survivalWorse survivalMale patientsMDS patientsRefractory anemiaResults ProgramClinical subtypesSEER dataSEER programMDS casesPatients