2013
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Li MD, Ruan HB, Hughes ME, Lee JS, Singh JP, Jones SP, Nitabach MN, Yang X. O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination. Cell Metabolism 2013, 17: 303-310. PMID: 23395176, PMCID: PMC3647362, DOI: 10.1016/j.cmet.2012.12.015.Peer-Reviewed Original ResearchConceptsCircadian clockProtein modificationNutrient-sensing pathwaysO-GlcNAc signalingHexosamine biosynthesis pathwayCovalent protein modificationBiosynthesis pathwayGlcNAc transferaseNutritional signalsClock oscillationsO-GlcNAcylationAberrant circadian rhythmsClock targetsOGT expressionCircadian oscillationsUbiquitinationN-acetylglucosamineNutrient fluxesMetabolic oscillationsBMAL1GenesPathwayCircadian rhythmKey mechanismClock
2006
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. Nuclear Receptor Expression Links the Circadian Clock to Metabolism. Cell 2006, 126: 801-810. PMID: 16923398, DOI: 10.1016/j.cell.2006.06.050.Peer-Reviewed Original ResearchConceptsNuclear receptor expressionReceptor expressionFat-soluble hormoneBrown adipose tissueKey metabolic tissuesPeripheral circadian clocksGlucose metabolismAdipose tissueDietary lipidsThyroid hormonesMetabolic tissuesKey target genesSkeletal muscleOrphan receptorNuclear receptorsEnergy metabolismNovel roleBasal metabolismHormoneMetabolismReceptorsCircadian clockExpression profilesMouse nuclear receptorsCircadian entrainment