2017
Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation
Zhang D, Xie Z, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Peng C, Ruan H, Wang D, Jensen L, Kwon O, Lee S, Pletcher S, Tan M, Lombard D, White K, Zhao H, Li J, Roeder R, Yang X, Zhao Y. Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.755.2.Peer-Reviewed Original ResearchKetone bodiesNeuro-protective roleDiabetic ketoacidosisAdjunctive treatmentKetogenic dietBrain tumorsPharmacological effectsNeurodegenerative diseasesPathophysiological statesCultured cell linesMedical FoundationLines of evidenceCell linesEpilepsyΒ-hydroxybutyrylationNIHRNA-seq analysisMetabolic regulationRegulatory roleGene expressionShanghai Municipal ScienceMetabolic pathwaysKetoacidosisDiabetesPatients
2016
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Molecular Cell 2016, 62: 194-206. PMID: 27105115, PMCID: PMC5540445, DOI: 10.1016/j.molcel.2016.03.036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesChromatin Assembly and DisassemblyDiabetic KetoacidosisDisease Models, AnimalEnergy MetabolismEpigenesis, GeneticFatty AcidsGene Expression RegulationGlucoseHEK293 CellsHistonesHumansHydroxybutyratesLiverLysineMice, Inbred C57BLPromoter Regions, GeneticProtein Processing, Post-TranslationalStarvationStreptozocinConceptsLysine β-hydroxybutyrylationΒ-hydroxybutyrylationActive gene promotersEpigenetic regulatory marksRNA-seq analysisHistone acetylation sitesChromatin regulationHistone marksChIP-seqAcetylation sitesProtein modificationGene promoterRegulatory marksDiverse functionsGene expressionMetabolic regulationMetabolic pathwaysCultured cellsPathophysiological statesRegulationExpressionNew avenuesKbhbMarksGenes