2023
Colorectal Carcinoma With Sarcomatoid Components
Golconda U, McHugh K, Allende D, Collins K, Henn P, Lacambra M, Bejarano P, Groisman G, Loughrey M, Monappa V, Zhang X, Hornick J, Gonzalez R. Colorectal Carcinoma With Sarcomatoid Components. The American Journal Of Surgical Pathology 2023, 48: 465-474. PMID: 38155543, DOI: 10.1097/pas.0000000000002172.Peer-Reviewed Original ResearchConceptsSarcomatoid componentColorectal carcinomaUndifferentiated carcinomaTumor-infiltrating lymphocytesNodal metastasisAbdominal painDistant metastasisRare subtypeSMARCA4 lossTumor buddingHeterologous elementsRepair protein expressionRectosigmoid regionSpindle cellsGastrointestinal bleedingKeratin-positivePoor prognosisFollow-upCarcinomaMismatch repair protein expressionMolecular testingAdvanced stageTumorLoss of mismatch repair protein expressionProtein expression
2019
Histologic patterns of liver injury induced by anti-PD-1 therapy
Zhang D, Hart J, Ding X, Zhang X, Feely M, Yassan L, Alpert L, Soldevila-Pico C, Zhang X, Liu X, Lai J. Histologic patterns of liver injury induced by anti-PD-1 therapy. Gastroenterology Report 2019, 8: 50-55. PMID: 32467761, PMCID: PMC7244961, DOI: 10.1093/gastro/goz044.Peer-Reviewed Original ResearchAnti-PD-1 therapyAnti-PD-1 treatmentLiver function testsHistologic patternAutoimmune hepatitisAdvanced malignanciesLiver injuryAbnormal liver function testsAnti-PD-1 agentsClassical autoimmune hepatitisLiver chemistry testsMultiple advanced malignanciesPD-1 inhibitorsSevere liver injuryCell death 1Different histologic patternsCholestatic injuryHepatitis panelSteroid therapyAbdominal painAcute hepatitisGastrointestinal symptomsImmunosuppressive therapyDrug cessationHistologic injury