2020
Hepatocellular Carcinoma Role of Pathology in the Era of Precision Medicine
Vyas M, Zhang X. Hepatocellular Carcinoma Role of Pathology in the Era of Precision Medicine. Clinics In Liver Disease 2020, 24: 591-610. PMID: 33012447, DOI: 10.1016/j.cld.2020.07.010.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaRole of pathologyTargetable genomic alterationsDistinct histologic subtypesConfirmation of diagnosisArchitectural growth patternRadiologic featuresHistologic subtypeHistopathologic diagnosisMolecular alterationsPersonalized careHeterogeneous tumorsPathologyPrecision oncologyGenomic alterationsPrecision medicineDiagnosisAlterations
2019
Macrotrabecular Hepatocellular Carcinoma
Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/pas.0000000000001289.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-FetoproteinsCarcinoma, HepatocellularDisease ProgressionFemaleHepatectomyHepatitis BHepatitis CHumansLiver CirrhosisLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingProgression-Free SurvivalRetrospective StudiesRisk FactorsTime FactorsTumor BurdenConceptsHepatocellular carcinomaHCC subtypesHigh alpha-fetoprotein levelsWorse recurrence-free survivalDistinct HCC subtypeHepatitis C infectionRecurrence-free survivalAlpha-fetoprotein levelsAnaplastic tumor cellsHigh histologic gradePoor overall survivalConventional hepatocellular carcinomaHigh recurrence rateHigher AJCC stageDetailed pathologic evaluationMacrotrabecular patternC infectionPrimary resectionHepatitis BOverall survivalPathologic evaluationAJCC stageClinicopathologic featuresHistologic subtypeRecurrence rate