2020
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
Benito-Vicente A, Uribe KB, Rotllan N, Ramírez CM, Jebari-Benslaiman S, Goedeke L, Canfrán-Duque A, Galicia-García U, De Urturi D, Aspichueta P, Suárez Y, Fernández-Hernando C, Martín C. miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression. International Journal Of Molecular Sciences 2020, 21: 8675. PMID: 33212990, PMCID: PMC7698485, DOI: 10.3390/ijms21228675.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin receptor substrate-1Type 2 diabetes mellitusHepatic insulin resistanceInsulin receptorInsulin receptor expressionImplication of microRNAsDiabetes mellitusHeart failureCardiometabolic pathologiesInsulin sensitivityReceptor expressionINSR expressionReceptor substrate-1Human hepatoma cellsHepatic tissueLipid metabolismObesityInsulinHigh expressionMiR-27Hepatoma cellsSubstrate-1Novel roleLiver
2016
SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
Price NL, Holtrup B, Kwei SL, Wabitsch M, Rodeheffer M, Bianchini L, Suárez Y, Fernández-Hernando C. SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation. Molecular And Cellular Biology 2016, 36: 1180-1193. PMID: 26830228, PMCID: PMC4800797, DOI: 10.1128/mcb.00745-15.Peer-Reviewed Original ResearchConceptsWhite adipose tissueCyclin-dependent kinase 6MiR-33bSREBP-1Adipocyte differentiationReceptor-γ target genesPeroxisome proliferator-activated receptor-γ target genesDevelopment of obesityStandard mouse modelSterol regulatory element-binding protein 2Lipid droplet formationLipid droplet accumulationIntronic microRNAsHost genesTarget genesMouse modelKinase 6Adipose tissueMetabolic diseasesNovel roleImportant regulatorHuman preadipocytesDroplet accumulationVivo assessmentProtein 2