2018
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight 2018, 3: e97918. PMID: 29563332, PMCID: PMC5926923, DOI: 10.1172/jci.insight.97918.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueAllelesAngiopoietin-Like Protein 4AnimalsAtherosclerosisBody WeightChemokinesCytokinesDiet, High-FatDiet, WesternFatty AcidsGene Expression ProfilingGene Expression RegulationGene Knockout TechniquesGlucoseInsulinIntegrasesIntercellular Signaling Peptides and ProteinsLipid MetabolismLipoprotein LipaseLipoproteinsLiverMaleMiceMice, Inbred C57BLMice, KnockoutMusclesObesityProprotein Convertase 9TriglyceridesConceptsAngiopoietin-like protein 4High-fat dietEctopic lipid depositionLipid depositionGlucose toleranceLipoprotein lipaseShort-term high-fat dietSevere metabolic abnormalitiesProgression of atherosclerosisMajor risk factorTriacylglycerol-rich lipoproteinsFatty acid uptakeAdipose tissue resultsProatherogenic lipoproteinsCardiometabolic diseasesMetabolic abnormalitiesKO miceRisk factorsWhole body lipidMetabolic disordersGlucose metabolismLPL activityAdipose tissueGenetic ablationRapid clearance
2010
MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function
Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC. MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function. Arteriosclerosis Thrombosis And Vascular Biology 2010, 30: 1118-1126. PMID: 20378849, PMCID: PMC2880481, DOI: 10.1161/atvbaha.109.200873.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAortaCell DifferentiationCell ProliferationCells, CulturedDEAD-box RNA HelicasesEmbryo LossEndoribonucleasesGene Expression Regulation, DevelopmentalGenotypeGestational AgeHemorrhageIntegrasesLiver DiseasesMaleMiceMice, KnockoutMicrofilament ProteinsMicroRNAsMuscle DevelopmentMuscle ProteinsMuscle, Smooth, VascularNuclear ProteinsPhenotypeRibonuclease IIIStress FibersTrans-ActivatorsTranscriptional ActivationTransfectionUmbilical ArteriesVasoconstrictionVasodilationConceptsLate embryonic lethalityFundamental cellular processesContractile differentiationContractile protein markersDicer-dependent miRNAsActin stress fibersDeletion of DicerRole of miRNAsDicer resultsOverexpression of microRNAEmbryonic lethalityMiRNA synthesisCellular processesRate-limiting enzymeStress fibersVascular developmentMuscle growthCell typesCellular proliferationMiRNAsVascular smooth muscle growthVascular smooth muscle proliferationMicroRNAsProtein markersDicer