Featured Publications
Genetic determinants for the racial disparities in the risk of prostate and testicular cancers
Uzamere I, Wang Y, Zheng T, Zhu Y. Genetic determinants for the racial disparities in the risk of prostate and testicular cancers. Communications Medicine 2022, 2: 138. PMID: 36352009, PMCID: PMC9630379, DOI: 10.1038/s43856-022-00205-5.Peer-Reviewed Original ResearchRisk of prostateTesticular cancerProstate cancerRisk allelesRacial disparitiesEuropean ancestryAfrican ancestryMethodsThe current studyLower incidenceIncidence disparitiesHigh incidenceRisk allele frequenciesCancerConclusionsOur findingsGenetic factorsMenT-testRegression analysisProstateIncidenceGenetic determinantsCurrent studyRiskAllele frequenciesDisparities
2006
Does “Clock” Matter in Prostate Cancer?
Zhu Y, Zheng T, Stevens RG, Zhang Y, Boyle P. Does “Clock” Matter in Prostate Cancer? Cancer Epidemiology Biomarkers & Prevention 2006, 15: 3-5. PMID: 16434577, PMCID: PMC2366206, DOI: 10.1158/1055-9965.epi-05-0631.Peer-Reviewed Original ResearchConceptsProstate cancerSex hormone levelsFemale breast cancerCommon cancer typesEvening shift workHormone levelsPrognostic biomarkerBreast cancerAndrogen expressionProstate tumorigenesisCancerCancer typesShift workDaily biochemicalIndividual riskEtiologyCircadian rhythmGenetic variantsRiskCircadian clockCircadian cycleBiomarkersPhysiologicProfound effect
2005
Occupation and Risk of Pancreatic Cancer: A Population-Based Case–Control Study in Iowa
Zhang Y, Cantor KP, Lynch CF, Zhu Y, Zheng T. Occupation and Risk of Pancreatic Cancer: A Population-Based Case–Control Study in Iowa. Journal Of Occupational And Environmental Medicine 2005, 47: 392-398. PMID: 15824631, DOI: 10.1097/01.jom.0000158707.88801.f5.Peer-Reviewed Original Research
2003
Telomere Dysfunction: A Potential Cancer Predisposition Factor
Wu X, Amos C, Zhu Y, Zhao H, Grossman B, Shay J, Luo S, Hong W, Spitz M. Telomere Dysfunction: A Potential Cancer Predisposition Factor. Journal Of The National Cancer Institute 2003, 95: 1211-1218. PMID: 12928346, DOI: 10.1093/jnci/djg011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, SouthernCarcinoma, Renal CellCase-Control StudiesDNA DamageDNA RepairDNA, NeoplasmFemaleFlow CytometryGenetic Predisposition to DiseaseHead and Neck NeoplasmsHumansIn Situ Hybridization, FluorescenceKidney NeoplasmsLung NeoplasmsLymphocytesMaleMiddle AgedNeoplasmsOdds RatioRisk AssessmentRisk FactorsSmokingTelomereUrinary Bladder NeoplasmsConceptsControl subjectsTelomere lengthNeck cancerOdds ratioCancer riskShort telomeresOngoing case-control studyPercent of patientsRenal cell cancerCase-control studyPeripheral blood lymphocytesLongest quartileCase patientsCell cancerSmoking statusDisease characteristicsBladder cancerBlood lymphocytesStratified analysisGenetic instabilityHuman bladderRenal cellsStudy participantsCancerPredisposition factors
2002
A case‐control analysis of lymphocytic chromosome 9 aberrations in lung cancer
Zhu Y, Spitz M, Strom S, Tomlinson G, Amos C, Minna J, Wu X. A case‐control analysis of lymphocytic chromosome 9 aberrations in lung cancer. International Journal Of Cancer 2002, 102: 536-540. PMID: 12432559, DOI: 10.1002/ijc.10762.Peer-Reviewed Original ResearchConceptsPeripheral blood lymphocytesChromosome 9 aberrationsLung cancerOdds ratioFamily historyPrimary lung tumorsLung cancer casesElevated odds ratiosCase-control analysisLung carcinoma specimensLung cancer predispositionFamily history analysisFrequent genetic changesEpidemiologic profileBlood lymphocytesLung tumorigenesisLung tumorsCancer casesCarcinoma specimensChromosome 9 abnormalitiesControl individualsCancerCytogenetic aberrationsFamilial aggregationChromosomal alterations