2014
Epigenome-wide analysis of piRNAs in gene-specific DNA methylation
Fu A, Jacobs D, Zhu Y. Epigenome-wide analysis of piRNAs in gene-specific DNA methylation. RNA Biology 2014, 11: 1301-1312. PMID: 25590657, PMCID: PMC4615395, DOI: 10.1080/15476286.2014.996091.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsGene-specific DNA methylationDNA methylationGenic lociTransposable elementsCpG sitesSilencing of transposable elementsGenome-wide methylation profilingDifferentially methylated CpG sitesGenome-wide effortsTarget CpG sitesInduce DNA methylationTransposon classesEpigenome-wide analysisIntergenic regionGenomic regionsNascent mRNAHuman genomeMethylation changesGenomic DNAMethylation profilesHuman somatic cellsUnique speciesGenome copiesSomatic cells
2004
An Evolutionary Perspective on Single-Nucleotide Polymorphism Screening in Molecular Cancer Epidemiology
Zhu Y, Spitz MR, Amos CI, Lin J, Schabath MB, Wu X. An Evolutionary Perspective on Single-Nucleotide Polymorphism Screening in Molecular Cancer Epidemiology. Cancer Research 2004, 64: 2251-2257. PMID: 15026370, DOI: 10.1158/0008-5472.can-03-2800.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsAmino acidsConservation levelDifferent cancer-related genesHuman DNA repair genesTolerance indexMolecular evolutionary approachEntire human genomeNonsynonymous single nucleotide polymorphismsSingle nucleotide polymorphism (SNP) screeningTarget single nucleotide polymorphismsDNA repair genesAmino acid changesEvolutionary conservationHuman genomeCancer-related genesMolecular epidemiological studiesSelective pressureMolecular cancer epidemiologyDifferent speciesPhenotypic functionsAcid changesRepair genesEvolutionary perspectivePolymorphism screening