2023
Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created Equal
Doroshow D, Wei W, Mehrotra M, Sia D, Eder J, Bindra R, Houldsworth J, LoRusso P, Walther Z. Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created Equal. Cancer Investigation 2023, 41: 646-655. PMID: 37505929, DOI: 10.1080/07357907.2023.2242957.Peer-Reviewed Original ResearchMeSH KeywordsBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaHumansIsocitrate DehydrogenaseMutationRetrospective StudiesConceptsClinical benefit rateIntrahepatic cholangiocarcinomaPlatinum sensitivityUnresectable intrahepatic cholangiocarcinomaObjective response rateMulticenter retrospective studyHomologous recombination repairDefective homologous recombination (HR) repairPrimary endpointPlatinum chemotherapyRetrospective studyPreclinical dataBenefit rateWildtype tumorsResponse rateMT tumorsWT diseasePatientsGene defectsCholangiocarcinomaTumors
2009
Isospora cholangiopathy: case study with histologic characterization and molecular confirmation
Walther Z, Topazian MD. Isospora cholangiopathy: case study with histologic characterization and molecular confirmation. Human Pathology 2009, 40: 1342-1346. PMID: 19447468, DOI: 10.1016/j.humpath.2009.01.020.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnimalsAnti-Infective AgentsAntiparasitic AgentsBile Ducts, ExtrahepaticBile Ducts, IntrahepaticBiopsyCholangiopancreatography, Endoscopic RetrogradeCholangitis, SclerosingHumansIsosporaIsosporiasisIvermectinMalePolymerase Chain ReactionTreatment OutcomeTrimethoprim, Sulfamethoxazole Drug CombinationConceptsAIDS patientsBile ductIsospora belliCommon bile duct biopsiesPolymerase chain reaction-based molecular analysisBile duct biopsyPrimary sclerosing cholangitisExtrahepatic bile ductRare opportunistic pathogenEndoscopic retrograde cholangiopancreatographyIntracellular protozoan parasiteDuct biopsySclerosing cholangitisUncommon causeAcute illnessHIV statusRadiologic findingsRetrograde cholangiopancreatographyTravelers' diarrheaWest African menHepatobiliary diseaseHistologic characterizationSmall intestineDiarrheaIsosporiasis