2022
A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients
Chen H, Morley K, Rodriguez R, Draeger E, Hassan M, Chen Z. A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients. Journal Of Applied Clinical Medical Physics 2022, 23: e13788. PMID: 36267043, PMCID: PMC9797158, DOI: 10.1002/acm2.13788.Peer-Reviewed Original Research
2019
Adaptive Imaging Versus Periodic Surveillance for Intrafraction Motion Management During Prostate Cancer Radiotherapy
Ma X, Yan H, Nath R, Chen Z, Li H, Liu W. Adaptive Imaging Versus Periodic Surveillance for Intrafraction Motion Management During Prostate Cancer Radiotherapy. Technology In Cancer Research & Treatment 2019, 18: 1533033819844489. PMID: 31177934, PMCID: PMC6558533, DOI: 10.1177/1533033819844489.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiation therapyRadiation therapyCouch shiftsAutomatic motion compensationAdaptive imagingAutomatic correctionCurrent clinical situationProstate cancer radiotherapyImaging surveillanceMotion compensationPeriodic imaging surveillanceProstate cancerPeriodic surveillanceClinical situationsSurveillance strategiesBenefits of adaptivePeriodic imagingArc therapyMean percentageTherapyIntrafraction motion managementCancer radiotherapyRadiation therapy simulationTherapy simulationBeam delivery
2017
Patterns of Dose Prescription and Recording in Stereotactic Body Radiation Therapy: A Multi-institutional Study
Das I, Andersen A, Bayliss A, Chen Z, Dimofte A, Huang L, Ai H, Langer M, Lee C, Popple R, Rice R, Schiff P, Zhu T. Patterns of Dose Prescription and Recording in Stereotactic Body Radiation Therapy: A Multi-institutional Study. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s68-s69. DOI: 10.1016/j.ijrobp.2017.06.167.Peer-Reviewed Original ResearchDose-Volume Predictors of Esophagitis After Thoracic Stereotactic Body Radiation Therapy
Harder EM, Chen Z, Park HS, Mancini BR, Decker RH. Dose-Volume Predictors of Esophagitis After Thoracic Stereotactic Body Radiation Therapy. American Journal Of Clinical Oncology 2017, 40: 477-482. PMID: 26017483, DOI: 10.1097/coc.0000000000000195.Peer-Reviewed Original ResearchConceptsStepwise selection techniqueRadiation therapyThoracic stereotactic body radiation therapyStereotactic hypofractionated radiation therapyStereotactic body radiation therapyDose-volume predictorsNormal tissue complication probabilityHypofractionated radiation therapyMultivariate logistic regressionProbability estimatesBody radiation therapyPlanning target volumeEsophageal toxicityEsophagitis ratesCTCAE v4.0Dosimetric predictorsPulmonary tumorsInstitutional databaseRadiotherapy parameters
2016
State of dose prescription and compliance to international standard (ICRU-83) in intensity modulated radiation therapy among academic institutions
Das IJ, Andersen A, Chen Z, Dimofte A, Glatstein E, Hoisak J, Huang L, Langer MP, Lee C, Pacella M, Popple RA, Rice R, Smilowitz J, Sponseller P, Zhu T. State of dose prescription and compliance to international standard (ICRU-83) in intensity modulated radiation therapy among academic institutions. Practical Radiation Oncology 2016, 7: e145-e155. PMID: 28274405, DOI: 10.1016/j.prro.2016.11.003.Peer-Reviewed Original ResearchConceptsDose-volume histogramsDose prescriptionRadiation therapyHomogeneity indexICRU-83Stereotactic body radiation therapyBody radiation therapyTreatment sitesInstitutional review board clearanceLung sitesClinical trialsPelvic sitesPrescribed doseInternational guidelinesTumor siteArc therapyPatient treatmentTarget volumeTherapyPatientsDoseLevels of dosePrescriptionP-valueDose deliveryPulmonary dose-volume predictors of radiation pneumonitis following stereotactic body radiation therapy
Harder EM, Park HS, Chen Z, Decker RH. Pulmonary dose-volume predictors of radiation pneumonitis following stereotactic body radiation therapy. Practical Radiation Oncology 2016, 6: e353-e359. PMID: 27156424, DOI: 10.1016/j.prro.2016.01.015.Peer-Reviewed Original ResearchConceptsMean lung doseStereotactic body radiation therapyRisk of gradeRadiation pneumonitisMultivariable logistic regressionBody radiation therapyDosimetric predictorsRadiation therapyMaximum doseLogistic regressionRP rateBest dosimetric predictorCardiac dosimetric parametersDose-volume predictorsPercent of lungVolume of lungGross tumor volumeBackward stepwise eliminationLung V10Lung doseMean doseTotal lungUnivariate analysisPulmonary volumesTumor volume
2015
Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy
Zhang Y, Wu H, Chen Z, Knisely JP, Nath R, Feng Z, Bao S, Deng J. Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 523-531. PMID: 26460994, DOI: 10.1016/j.ijrobp.2015.06.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAorta, ThoracicBody SizeBreastChildChild, PreschoolCone-Beam Computed TomographyFemaleHeartHumansLungMaleMiddle AgedMonte Carlo MethodOrgans at RiskPhantoms, ImagingPhotonsPrecision MedicineProtonsRadiation DosageRadiography, ThoracicRadiotherapy, Image-GuidedRisk AssessmentSex FactorsSpinal CordThoracic WallThoraxConceptsConcomitant imaging doseThoracic radiation therapyCancer riskRadiation therapyMean dosesCardiac substructuresKilovoltage cone-beamImaging doseAdverse eventsPediatric patientsMedian dosesCancer patientsRight ventricleExtra radiation doseSpinal cordHigh dosesPatientsCone beamPlanning CT imagesChest dimensionsDosesPatient sizeImaging guidanceTherapyDose
2014
Personalized Quantification of Imaging Doses to Children and Adults Scanned by Standard Thoracic Cone Beam CT in Radiation Therapy
Zhang Y, Wu H, Chen Z, Knisely J, Nath R, Yue H, Feng Z, Bao S, Deng J. Personalized Quantification of Imaging Doses to Children and Adults Scanned by Standard Thoracic Cone Beam CT in Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s76. DOI: 10.1016/j.ijrobp.2014.05.453.Peer-Reviewed Original Research
2011
A novel modified dynamic conformal arc technique for treatment of peripheral lung tumors using stereotactic body radiation therapy
Ross CC, Kim JJ, Chen ZJ, Grew DJ, Chang BW, Decker RH. A novel modified dynamic conformal arc technique for treatment of peripheral lung tumors using stereotactic body radiation therapy. Practical Radiation Oncology 2011, 1: 126-134. PMID: 24673926, DOI: 10.1016/j.prro.2010.11.002.Peer-Reviewed Original ResearchNormal tissue dose constraintsStereotactic body radiation therapyBody radiation therapyDynamic conformal arc techniqueRadiation therapyDose constraintsNon-small cell lung cancerLung stereotactic body radiation therapyChest wall doseMedian lung V20RTOG 0236 protocolPeripheral lung tumorsCell lung cancerNormal tissue constraintsLower maximum doseTreatment volume coverageRTOG protocolInoperable patientsConsecutive patientsLung V20Lung doseLung cancerPTV coverageLung tumorsSeparate cohort
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxia
2009
Impact of Kilo-Voltage Cone Beam Computed Tomography on Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Nath R. Impact of Kilo-Voltage Cone Beam Computed Tomography on Image-Guided Radiotherapy of Prostate Cancer. IFMBE Proceedings 2009, 25/1: 17-20. DOI: 10.1007/978-3-642-03474-9_5.Peer-Reviewed Original ResearchKilo-voltage cone beamProstate cancerImage-guided radiotherapyDosevolume histogramsExcessive dosesCone beamFemur headAdjacent critical structuresPatient anatomyTesticular doseCBCT dosesTesticular dosesImage-guided radiation therapyRadiation therapyMost dosesSuperior-inferior directionDVH analysisCritical organsCancerDosesIGRT treatmentReal patient anatomyDosimetric impactScanning protocolPosterior side
2004
Iodine 125 Versus Palladium 103 Implants for Prostate Cancer
Peschel RE, Colberg JW, Chen Z, Nath R, Wilson LD. Iodine 125 Versus Palladium 103 Implants for Prostate Cancer. The Cancer Journal 2004, 10: 170-174. PMID: 15285926, DOI: 10.1097/00130404-200405000-00006.Peer-Reviewed Original ResearchConceptsExternal beam radiation therapyMinimum tumor doseDisease-free survival ratesComplication rateTumor doseProstate cancerRadiation therapyClinical outcomesPrognostic groupsBiochemical disease-free survival ratesSurvival rateBiochemical disease-free survivalDisease-free survivalHigh complication ratePoor prognostic groupProstate-specific antigenHormonal therapyT stageGleason scoreSingle institutionTransperineal implantationFavorable groupGrade 3Treatment groupsPatients