2024
Detecting time‐varying genetic effects in Alzheimer's disease using a longitudinal genome‐wide association studies model
Zhuang X, Xu G, Amei A, Cordes D, Wang Z, Oh E, Initiative F. Detecting time‐varying genetic effects in Alzheimer's disease using a longitudinal genome‐wide association studies model. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2024, 16: e12597. PMID: 38855650, PMCID: PMC11157162, DOI: 10.1002/dad2.12597.Peer-Reviewed Original ResearchGenome-wide association studiesSingle nucleotide polymorphismsLongitudinal genome-wide association studiesGWAS modelsAssociation studiesGenetic effectsAlzheimer's diseaseSingle nucleotide polymorphism effectsNational Alzheimer's Coordinating Center dataAge-dependent genetic effectsImpairment statusProgression of Alzheimer's diseaseEffects of apoEAge-stratified analysesGenetic signalsGenetic lociNucleotide polymorphismsLongitudinal phenotypesPathway analysisInitiative participantsAmyloid accumulationAmyloidStandardized uptake value ratioCenter dataAmyloid positron emission tomography
2023
Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits
Cheng Y, Justice A, Wang Z, Li B, Hancock D, Johnson E, Xu K. Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits. BMC Genomics 2023, 24: 556. PMID: 37730558, PMCID: PMC10510240, DOI: 10.1186/s12864-023-09661-2.Peer-Reviewed Original ResearchConceptsDNA methylationMultiple traitsPleiotropic effectsGenetic variantsAberrant DNA methylationPhenome-wide association studyCis-meQTLsComplex traitsRelevant traitsDNAm sitesEnrichment analysisMeQTLsAssociation studiesSignificant traitsTraitsImmune pathwaysMethylationNew insightsMendelian randomizationImmunological functionsGenesVariantsCausal rolePathwayCpG