2022
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells
Kshitiz, Afzal J, Suhail Y, Chang H, Hubbi M, Hamidzadeh A, Goyal R, Liu Y, Sun P, Nicoli S, Dang C, Levchenko A. Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells. Cell Systems 2022, 13: 1048-1064.e7. PMID: 36462504, PMCID: PMC10012408, DOI: 10.1016/j.cels.2022.11.003.Peer-Reviewed Original ResearchConceptsHIF-1α activityActivation of genesChaperone-mediated autophagyCancer cellsCell divisionIndividual cancer cellsRegulated processPatient-derived cancer cellsSubset of cellsMolecular mechanismsFluorescent reportersSingle-cell responsesCancer cell linesCell linesGenesHypoxic tumor cellsHIF-1αHypoxic conditionsCellsBroad suppressionAggressive growthTumor cellsHypoxic cellsOscillatory activityExtracellular lactate
2014
Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer
Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, Denduluri A, Chaichana K, Li Q, Zhang H, Levchenko A, Guerrero-Cazares H, Quiñones-Hinojosa A. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death & Disease 2014, 5: e1567-e1567. PMID: 25501828, PMCID: PMC4649837, DOI: 10.1038/cddis.2014.521.Peer-Reviewed Original ResearchConceptsHuman adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsBrain tumor-initiating cellsAnti-inflammatory propertiesStem cellsAmyotrophic lateral sclerosisTumor-associated fibroblastsTumor-initiating cellsBrain cancer cellsMyocardial infarctionHypoxic culture conditionsClinical investigationLateral sclerosisLess cell deathBrain cancerMigratory capabilityCancer cellsLow oxygen tensionOxygen tensionRegenerative potentialMultipotent cellsAnticancer propertiesCell deathHypoxia
2000
Evaluation of 11C-colchicine for PET imaging of multiple drug resistance.
Levchenko A, Mehta B, Lee J, Humm J, Augensen F, Squire O, Kothari P, Finn R, Leonard E, Larson S. Evaluation of 11C-colchicine for PET imaging of multiple drug resistance. Journal Of Nuclear Medicine 2000, 41: 493-501. PMID: 10716325.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesColchicineDrug Resistance, MultipleFlow CytometryHumansMiceMice, Inbred BALB CModels, TheoreticalNeuroblastomaRatsRats, NudeTissue DistributionTomography, Emission-ComputedTransplantation, HeterologousTumor Cells, CulturedConceptsResistant tumorsPET imagingMultiple drug resistance phenotypeDrug-resistant variantsQuality of lifeCell linesMultiple drug resistanceResistant cell linesC cell lineP-gp actionDrug resistance phenotypeEarly diagnosisNude ratsFDG scansTumorsP-glycoproteinDrug resistanceBiodistribution experimentsCytotoxic agentsChemotherapeutic interventionResistant strainsCancer cellsIntracellular accumulationVivo experimentsScans