2024
Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchMeSH KeywordsCell CommunicationCell DifferentiationEndothelial CellsMorphogenesisSignal TransductionConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectin
2004
The Systems Biology of Glycosylation
Murrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation. ChemBioChem 2004, 5: 1334-1347. PMID: 15457533, DOI: 10.1002/cbic.200400143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbohydratesCell CommunicationEukaryotic CellsGlycosylationHumansModels, BiologicalSignal TransductionSystems BiologyConceptsSystems biologyRegulation of differentiationRegulation of glycosylationEukaryotic cellsBiochemical systems analysisCell regulation processesCell decisionsSignal transductionGlycosylationBiologyRegulation processesRegulationTransductionApoptosisDifferentiationProfound influenceCellsNovel research methodology
2003
Dynamical and integrative cell signaling: challenges for the new biology
Levchenko A. Dynamical and integrative cell signaling: challenges for the new biology. Biotechnology And Bioengineering 2003, 84: 773-782. PMID: 14708118, DOI: 10.1002/bit.10854.Peer-Reviewed Original ResearchConceptsProtein-centric approachSystems biology approachSignal transduction pathwaysNeural networkHigh-fidelity informationCareful experimental analysisBiology approachStatic worldTransduction pathwaysCell signalingPostgenomic eraHigh-throughput analysisIntracellular networksNetworkComplex networksNew biologyVolatile environmentBiological researchNotion of concentrationStructural viewBiochemical reactionsDynamical viewExperimental analysisPathwayPrimary determinant