2024
Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchMeSH KeywordsCell CommunicationCell DifferentiationEndothelial CellsMorphogenesisSignal TransductionConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectin
2014
Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer
Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, Denduluri A, Chaichana K, Li Q, Zhang H, Levchenko A, Guerrero-Cazares H, Quiñones-Hinojosa A. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death & Disease 2014, 5: e1567-e1567. PMID: 25501828, PMCID: PMC4649837, DOI: 10.1038/cddis.2014.521.Peer-Reviewed Original ResearchConceptsHuman adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsBrain tumor-initiating cellsAnti-inflammatory propertiesStem cellsAmyotrophic lateral sclerosisTumor-associated fibroblastsTumor-initiating cellsBrain cancer cellsMyocardial infarctionHypoxic culture conditionsClinical investigationLateral sclerosisLess cell deathBrain cancerMigratory capabilityCancer cellsLow oxygen tensionOxygen tensionRegenerative potentialMultipotent cellsAnticancer propertiesCell deathHypoxia
2005
Proteomics takes stem cell analyses to another level
Levchenko A. Proteomics takes stem cell analyses to another level. Nature Biotechnology 2005, 23: 828-830. PMID: 16003369, DOI: 10.1038/nbt0705-828.Peer-Reviewed Original Research