2023
Calcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanisms
2020
Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments
Nguyen L, Fischer T, Ehrlich B. Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00558.Peer-Reviewed Original ResearchCognitive impairmentNeuroprotective effectsChemotherapy-induced cognitive impairmentProtein kinase CPotential neuroprotective effectsGolgi-Cox stainingLife-saving treatmentSpatial memory acquisitionCancer survivorsLast injectionSpine densityCancer patientsNeurological dysfunctionDendritic arborizationIntraperitoneal injectionLithium pretreatmentPaclitaxel injectionMouse modelPaclitaxel treatmentSide effectsCellular deficitsSpecific cognitive functionsNeurodegenerative disordersCognitive functionImpairment