2018
Role of the mechanosensitive ion channel Piezo1 in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Chebib F, Beyder A, Wang X, Alcaino C, Ehrlich B, Torres V. Role of the mechanosensitive ion channel Piezo1 in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The FASEB Journal 2018, 32: 868.2-868.2. DOI: 10.1096/fasebj.2018.32.1_supplement.868.2.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseCalcium entryCyclic AMPMIMCD3 cellsCytoplasmic calciumFluid shear stressWild-type miceDominant polycystic kidney diseaseRenal cystogenesisFull-text articlesNon-selective cation channelsPolycystic kidney diseaseKidney diseaseExperimental Biology 2018 MeetingIntracellular calciumType miceVivo effectsPathogenic mechanismsCystic epitheliumLive-cell imagingMechanosensitive ion channelsSecretory phenotypeATP releaseMechanosensitive ion channel Piezo1Cation channels
2000
Conservation of localization patterns of IP3 receptor type 1 in cerebellar Purkinje cells across vertebrate species
Koulen P, Janowitz T, Johnston L, Ehrlich B. Conservation of localization patterns of IP3 receptor type 1 in cerebellar Purkinje cells across vertebrate species. Journal Of Neuroscience Research 2000, 61: 493-499. PMID: 10956418, DOI: 10.1002/1097-4547(20000901)61:5<493::aid-jnr3>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsHigh expression levelsVertebrate speciesDifferent vertebrate speciesPhylogenetic developmentNumber of speciesExpression levelsType 1 proteinIP3 receptor type 1Distribution of inositolLocalization patternsMolecular levelPurkinje cellsFluorescence immunocytochemistryCellular levelSpeciesFunctional differencesPolyclonal antiserumAdult cerebellumCerebellar Purkinje cellsReceptor type 1CellsConservationIntracellular calciumOrganismsPurkinje cell dendritesRegulation of the Type III InsP3 Receptor by InsP3 and ATP
Hagar R, Ehrlich B. Regulation of the Type III InsP3 Receptor by InsP3 and ATP. Biophysical Journal 2000, 79: 271-278. PMID: 10866953, PMCID: PMC1300931, DOI: 10.1016/s0006-3495(00)76289-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAllosteric RegulationAnimalsBinding, CompetitiveCalcium ChannelsDose-Response Relationship, DrugEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinomaMicrosomesProtein IsoformsRatsReceptors, Cytoplasmic and NuclearSubstrate SpecificityTumor Cells, CulturedConceptsType IIIChannel activityIntracellular calciumMaximal channel activityATP concentrationProlonged stimulationDependent inhibitionAllosteric modulationInsP3 receptorEnhanced channel activityType IOpen probabilityOpen timeReceptorsHigh ATP concentrationsHigh levelsATPLow ATP concentrationsIsoformsActivity
1996
Ligand-gated calcium channels inside and out
Striggow F, Ehrlich B. Ligand-gated calcium channels inside and out. Current Opinion In Cell Biology 1996, 8: 490-495. PMID: 8791458, DOI: 10.1016/s0955-0674(96)80025-1.Peer-Reviewed Original ResearchConceptsLigand-gated calcium channelsStore-operated channelsCalcium-permeable channelsIntracellular membranesFunctional characterizationPlasma membraneAllosteric mechanismAssociated proteinsTrisphosphate receptorCalcium releaseRyanodine receptorIntracellular storesIntracellular calciumCalcium channelsMembraneReceptorsProteinTypes of channelsInositolRelease