2024
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Ogino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024, 134: e171691. PMID: 38916955, PMCID: PMC11324315, DOI: 10.1172/jci171691.Peer-Reviewed Original ResearchAlcohol-associated hepatitisReduced cell proliferationCalcium channel expressionCalcium signaling mechanismsIntracellular calcium channelsCell proliferationRegulate calcium signalingNeutrophil extracellular trapsChannel expressionNeutrophil granule proteinsCalcium channelsNeutrophil infiltrationPatient specimensGranule proteasesMouse modelHealthy subjectsLiver diseaseExtracellular trapsCalcium signalingSerpin E2NeutrophilsElastase activityHepatitisTissue remodelingSignaling mechanisms
2020
Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments
Nguyen L, Fischer T, Ehrlich B. Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00558.Peer-Reviewed Original ResearchCognitive impairmentNeuroprotective effectsChemotherapy-induced cognitive impairmentProtein kinase CPotential neuroprotective effectsGolgi-Cox stainingLife-saving treatmentSpatial memory acquisitionCancer survivorsLast injectionSpine densityCancer patientsNeurological dysfunctionDendritic arborizationIntraperitoneal injectionLithium pretreatmentPaclitaxel injectionMouse modelPaclitaxel treatmentSide effectsCellular deficitsSpecific cognitive functionsNeurodegenerative disordersCognitive functionImpairment