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Benjamin Turk, PhD

he/him/his
Professor of Pharmacology
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Contact Info

Pharmacology

PO Box 208066, 333 Cedar Street

New Haven, CT 06520-8066

United States

Education

PhD
Massachusetts Institute of Technology (1999)


BA
Oberlin College (1990)


Additional Titles

Director of Medical Studies, Pharmacology

About

Titles

Professor of Pharmacology

Director of Medical Studies, Pharmacology

Appointments

Education & Training

Postdoc
Harvard Medical School (2004)
PhD
Massachusetts Institute of Technology (1999)
BA
Oberlin College (1990)

Research

Overview

The goal of our research is to understand the molecular mechanisms underlying cellular phosphorylation networks, and how these networks are re-wired in cancer cells. The human genome encodes over 500 protein kinases, and mass spectrometry based phosphoproteomics efforts have now cataloged over 100,000 sites of phosphorylation in mammalian cells. These studies have outpaced our ability to understand signaling networks through analysis of individual kinases and their substrates: for the vast majority of the phosphorylation sites, the responsible kinase and functional significance are simply not known. My group studies basic mechanisms used by kinases to target specific substrates within the cell, with the idea of applying this knowledge to identify new kinase-substrate pairs on a proteomic scale. Kinases interact with their substrates through short sequence motifs found both at the site of phosphorylation and at distal sites. We have recently conducted a biochemical screen to identify phosphorylation site motifs recognized by the entire set of human kinases. Information from these screens is used to map cellular phosphorylation networks and to relate mechanisms of substrate targeting to specific structural features of kinases. As an extension of these studies, we are also examining how cancer-associated kinase mutations and treatment with kinase inhibitor drugs lead to "re-wiring" of phosphorylation networks. We are also developing new methodology to identify short linear motifs (SLiMs) in substrates and other interactors that bind to grooves and pockets outside of the kinase catalytic cleft. One outcome of this work is the identification of new strategies and agents for pharmacological targeting of signaling pathways relevant to disease.

Medical Subject Headings (MeSH)

Carcinogenesis; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Molecular Mechanisms of Pharmacological Action; Peptide Library; Protein Engineering; Protein Kinases; Proteomics; Signal Transduction

Research at a Glance

Research Interests

Research topics Benjamin Turk is interested in exploring.

Publications

Featured Publications

2024

2023

2022

2021

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