2023
Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samples
2021
Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Current Environmental Health Reports 2021, 8: 7-22. PMID: 33420964, DOI: 10.1007/s40572-020-00298-x.Peer-Reviewed Original ResearchConceptsAir pollutant exposureAdverse health effectsSpecific adverse health effectsOxidative stressHealth effectsPerturbation of metabolitesAir pollution exposureUntargeted metabolomicsPollutant exposureSteroid metabolic pathwaysPregnant womenInflammatory responseDisease continuumReviewThe purposeHealth outcomesLarger sample sizeMetabolic pathwaysDisease statusPollution exposureIdentified metabolitesMetabolic perturbationsMetabolic changesSummaryOur reviewAir pollution componentsMetabolomic analysis
2020
Analyzing Metabolomics Data for Environmental Health and Exposome Research
Cai Y, Rosen Vollmar AK, Johnson CH. Analyzing Metabolomics Data for Environmental Health and Exposome Research. Methods In Molecular Biology 2020, 2104: 447-467. PMID: 31953830, DOI: 10.1007/978-1-0716-0239-3_22.Peer-Reviewed Original ResearchConceptsLiquid chromatography-mass spectrometryChromatography-mass spectrometryBiological samplesExposure chemicalsExternal exposureSimultaneous analysisExposome researchHealth outcomesDisease preventionUnique advantagesBiological responsesUntargeted metabolomicsExposure risk assessmentHost susceptibilityMetabolomics technologyExposomeMetabolomic analysisRecent advancesSpectrometryExposureUntargeted metabolomics dataMetabolomicsHuman healthMetabolomics dataCumulative measure
2019
Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches
Vollmar A, Rattray NJW, Cai Y, Santos-Neto ÁJ, Deziel NC, Jukic AMZ, Johnson CH. Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches. Metabolites 2019, 9: 198. PMID: 31546636, PMCID: PMC6835889, DOI: 10.3390/metabo9100198.Peer-Reviewed Original ResearchUrinary metabolomics dataKidney functionOrthogonal partial least squares discriminant analysisUntargeted mass spectrometry-based metabolomics analysisCreatinine adjustmentUrine samplesMetabolomic analysisEarly-life exposomeMass spectrometry-based metabolomics analysisTime of conceptionSpecific gravity adjustmentCritical developmental windowMaternal urineEarly pregnancyPericonceptional periodUrinary concentrationsPost-implantation samplesUrinary dilutionUntargeted metabolomics analysisUrine concentrationsUnsupervised principal component analysisStudy objectiveDevelopmental windowMetabolomics dataMetabolomics studies
2016
Metabolite and Microbiome Interplay in Cancer Immunotherapy
Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Metabolite and Microbiome Interplay in Cancer Immunotherapy. Cancer Research 2016, 76: 6146-6152. PMID: 27729325, PMCID: PMC5093024, DOI: 10.1158/0008-5472.can-16-0309.Peer-Reviewed Original ResearchConceptsMicrobial interactionsRole of metabolitesCancer metabolismColon cancerHost microbiomeBiological originCancer progressionAdenoma/carcinomaPolysaccharide matrixTherapeutic designMetabolomic analysisPotential modulatorsMechanism of actionMicrobiomePolyamine metabolitesCancer immunotherapyBacteriaProximal colonBiofilmsProtective biofilmRecent studiesCancer treatmentMetabolismFuture targetsMetabolites