2019
An unbiased approach de-livers unexpected insight into torsin biology
Prophet SM, Schlieker C. An unbiased approach de-livers unexpected insight into torsin biology. Journal Of Clinical Investigation 2019, 129: 4576-4579. PMID: 31589164, PMCID: PMC6819095, DOI: 10.1172/jci132442.Peer-Reviewed Original ResearchConceptsFatty liver diseaseHepatic lipid metabolismLiver diseaseNonneural tissuesLipid metabolismBrain functionConditional deletionCongenital disorderDisease etiologySecretion defectHuman pathologiesMammalian liverPolypeptide 1Future investigationsSteatohepatitisUnbiased approachDysfunctionVLDLEtiologyMutationsDiseaseMiceLiverNeuronsPathology
2012
A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation
Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood 2012, 121: 1145-1156. PMID: 23243279, PMCID: PMC3575758, DOI: 10.1182/blood-2012-08-447409.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntigen-Presenting CellsATP Binding Cassette Transporter, Subfamily B, Member 2ATP-Binding Cassette TransportersBrefeldin ACD8-Positive T-LymphocytesCross-PrimingFemaleHydrogen-Ion ConcentrationImmunizationMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMutation, MissenseOvalbuminPeptide FragmentsRhadinovirusUbiquitin ThiolesteraseConceptsAntigen presenting cellsT cellsPresent exogenous antigensRecombinant herpes virusT cell responsesExogenous antigensPresenting cellsSIINFEKL peptideRecombinant influenzaAntigen processingInclusion of inhibitorsEnhanced expansionMHV-68AntigenImmunizationInfectionVirusCellsCrosspresentationImproved controlInfluenzaMiceSIINFEKL
2007
A Functional Ubiquitin-Specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection
Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL. A Functional Ubiquitin-Specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection. Journal Of Virology 2007, 81: 10300-10309. PMID: 17634221, PMCID: PMC2045495, DOI: 10.1128/jvi.01149-07.Peer-Reviewed Original ResearchConceptsLarge tegument proteinTegument proteinsMHV-68-infected cellsCysteine protease domainUbiquitin-specific proteaseAmino-terminal segmentActive site-directed probesActivity-based profilingDeubiquitinating proteaseEnzymatic functionSite-directed probesProtease domainBetaherpesvirus familyProteinORF64Murine gammaherpesvirus 68Tandem mass spectrometryProteaseGammaherpesvirus 68Course of infectionMass spectrometryHerpes simplex virus type 1Simplex virus type 1CellsUL36