2023
Bilateral Breast Cancer With Contralateral Axillary Metastasis Warrants Aggressive Treatment: Let's Go for It!
Mokhtech M, Knowlton C. Bilateral Breast Cancer With Contralateral Axillary Metastasis Warrants Aggressive Treatment: Let's Go for It! International Journal Of Radiation Oncology • Biology • Physics 2023, 117: 527-528. PMID: 37739602, DOI: 10.1016/j.ijrobp.2023.03.039.Peer-Reviewed Original Research
2022
Risk Assessment in the Molecular Era
Knowlton CA, Jimenez RB, Moran MS. Risk Assessment in the Molecular Era. Seminars In Radiation Oncology 2022, 32: 189-197. PMID: 35688517, DOI: 10.1016/j.semradonc.2022.01.005.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryClinical-pathologic featuresHormone receptor-positive diseaseLow-risk DCIS patientsLow-risk DCISAdjuvant endocrine therapyLocal control rateMajority of patientsSpecific survival outcomesPersonalized risk assessmentMolecular assaysBreast recurrenceDCIS patientsDCIS ScoreRT recommendationsDefinitive surgeryEndocrine therapyPostoperative radiotherapyPositive diseaseDuctal carcinomaSurvival outcomesControl rateInvasive cancerTreatment paradigmBreast cancer
2021
Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated
Peters GW, Gao SJ, Knowlton C, Zhang A, Evans SB, Higgins S, Wilson LD, Saltmarsh N, Picone M, Moran MS. Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated. Practical Radiation Oncology 2021, 12: e7-e12. PMID: 34508890, DOI: 10.1016/j.prro.2021.08.010.Peer-Reviewed Original ResearchConceptsRight-sided breast cancerRegional nodal irradiationLiver VBreast cancerLung VDIBH plansLiver parametersLung doseComprehensive regional nodal irradiationLeft-sided breast cancerRight breast cancerWilcoxon signed-rank testingRegional lymph nodesTotal liver volumeIpsilateral lung VLiver DHeart VNodal irradiationRBC patientsHeart doseLymph nodesInspiratory breathLiver volumeLarge cohortTreatment planCLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated
Peters G, Gao S, Knowlton C, Zhang A, Evans S, Higgins S, Wilson L, Saltmarsh N, Picone M, Moran M. CLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated. Journal Of The National Comprehensive Cancer Network 2021, 19: clo21-025. DOI: 10.6004/jnccn.2020.7707.Peer-Reviewed Original Research
2019
Standard Tangential Radiation Fields Do Not Provide Incidental Coverage to the Internal Mammary Nodes
Loganadane G, Kassick M, Kann BH, Young MR, Knowlton CA, Evans SB, Higgins SA, Belkacemi Y, Potenziani M, Saltmarsh N, Wilson LD, Moran MS. Standard Tangential Radiation Fields Do Not Provide Incidental Coverage to the Internal Mammary Nodes. Practical Radiation Oncology 2019, 10: 21-28. PMID: 31394256, DOI: 10.1016/j.prro.2019.07.014.Peer-Reviewed Original ResearchConceptsInternal mammary nodesClinical target volumePlanning target volumeIMN chainMean doseTangential radiation fieldsTarget volumePostmastectomy radiationMammary nodesRadiation therapyAdjuvant whole breast radiation therapyWhole breast radiation therapyRegional nodal radiationConformal radiation therapyNodal radiationPrimary endpointMedian doseTherapeutic coverageStudy cohortTherapeutic dosesBreast cancerIncidental doseAxillary fieldKruskal-Wallis testSupraclavicular fieldPV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB
Chowdhary M, Lee A, Gao S, Barry P, Diaz R, Bagadiya N, Park H, Yu J, Wilson L, Moran M, Higgins S, Knowlton C, Patel K. PV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB. Radiotherapy And Oncology 2019, 133: s15. DOI: 10.1016/s0167-8140(19)30465-7.Peer-Reviewed Original ResearchPatient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation
Rahimy E, Weidhaas J, Wei W, Lannin D, Horowitz N, Higgins S, Wilson LD, Knowlton C, Moran MS, Young MR, Killelea B, Chagpar A, Yeboa DN, Zelterman D, Evans S. Patient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation. Practical Radiation Oncology 2019, 9: e257-e265. PMID: 30796975, DOI: 10.1016/j.prro.2019.01.013.Peer-Reviewed Original ResearchConceptsPartial breast irradiationDosimetric constraintsBreast irradiationCosmetic outcomePoor cosmesisToxicity gradeBreast cancerKarnofsky performance status scoreTarget volumeAccelerated Partial Breast IrradiationSmaller planning target volumesAcceptable cosmetic outcomeAdverse cosmetic outcomePathologic tumor sizePerformance status scoreI breast cancerBreast-conserving surgeryThree-dimensional conformalDose-volume relationshipPlanning target volumeComputed tomography simulationDaily image guidanceLocoregional recurrencePrimary endpointTumor sizeIs Proton Therapy a “Pro” for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database
Chowdhary M, Lee A, Gao S, Wang D, Barry PN, Diaz R, Bagadiya NR, Park HS, Yu JB, Wilson LD, Moran MS, Higgins SA, Knowlton CA, Patel KR. Is Proton Therapy a “Pro” for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database. Frontiers In Oncology 2019, 8: 678. PMID: 30693271, PMCID: PMC6339938, DOI: 10.3389/fonc.2018.00678.Peer-Reviewed Original ResearchLymph node irradiationNational Cancer DatabaseOverall survivalMultivariable analysisBreast cancerCancer DatabaseProton radiotherapyNon-metastatic breast cancerCox proportional hazards modelHigher heart dosesN2-N3 diseaseMultivariate logistic analysisProportional hazards modelAcademic facilitiesLogistic regression modelsHeart dosesAdjuvant radiotherapyNode irradiationHazard ratioNode positivityClinical benefitClinical trialsPRT patientsStage 0Hazards model