2021
Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice
Huang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.Peer-Reviewed Original ResearchWeeks of dietNC miceHF miceHigher body fatProtein carbonylsOxidative stressAge miceBody fatChronic diet-induced obesityDiet-induced obese miceObesity-related disruptionIndependent risk factorInsulin tolerance testingHigh-fat chowLong-term obesitySeverity of obesityC57BL/6 female miceDiet-induced obesityHigh fat consumptionUterine oxidative stressCYP enzymatic activitiesAge-dependent increaseElevated oxidative stressDNA damageCytochrome P450 expression
2018
Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign Endometrium
COOKE K, DUN E, ANAM A, FLANNERY C. Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign Endometrium. Diabetes 2018, 67 DOI: 10.2337/db18-302-lb.Peer-Reviewed Original ResearchEndometrial adenocarcinomaType 2 diabetesBenign hyperplasiaPostmenopausal womenBMI distributionEC pathogenesisMore premenopausal womenRole of obesityIndependent risk factorWomen age 50T-testStudent's t-testBMI 25Premenopausal womenLow HDLObese womenEndometrial cancerHigh triglyceridesTotal cholesterolHigher BMIMetabolic abnormalitiesProspective studyBenign endometriumMedical recordsRisk factors