Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol
Kelly K, Huang J, Joshi A, Tal A, Wong S, Flannery C. Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol. Journal Of The Endocrine Society 2021, 5: a750-a751. DOI: 10.1210/jendso/bvab048.1526.Peer-Reviewed Original ResearchUnopposed estradiolWT miceMKR miceEndometrial adenocarcinomaNuclear atypiaExact testPlacebo-treated miceSetting of hyperinsulinemiaInsulin tolerance testingNormal-weight womenSetting of obesityEffects of estradiolCohort of miceFischer's exact testLower body weightOxidative stress-induced damagePercent body fatDNA damageBlinded histological analysisPartial hysterectomyWeight womenAnovulatory cyclesEndometrial glandsHyperinsulinemic miceCystic dilationObesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice
Huang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.Peer-Reviewed Original ResearchWeeks of dietNC miceHF miceHigher body fatProtein carbonylsOxidative stressAge miceBody fatChronic diet-induced obesityDiet-induced obese miceObesity-related disruptionIndependent risk factorInsulin tolerance testingHigh-fat chowLong-term obesitySeverity of obesityC57BL/6 female miceDiet-induced obesityHigh fat consumptionUterine oxidative stressCYP enzymatic activitiesAge-dependent increaseElevated oxidative stressDNA damageCytochrome P450 expression