2022
Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.
Saleh FL, Joshi AA, Tal A, Xu P, Hens J, Wong SL, Flannery C. Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice. Journal Of Endocrinology 2022, 254: 121-135. PMID: 35904489, PMCID: PMC9837806, DOI: 10.1530/joe-21-0447.Peer-Reviewed Original ResearchConceptsVaginal openingInsulin resistanceDay of VOIGF-1 levelsInsulin-like growth factor 1 receptorGreater insulin resistanceHigher insulin levelsEffect of hyperinsulinemiaGrowth factor 1 receptorGonadotropin-releasing hormoneLower body weightFactor 1 receptorReceptor isoform expressionMammary gland developmentLH levelsInsulin levelsInsulin receptor isoform expressionKisspeptin expressionChildhood obesityFemale miceHormone levelsEarly initiationHyperinsulinemiaBody weightOvarian follicles
2021
Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol
Kelly K, Huang J, Joshi A, Tal A, Wong S, Flannery C. Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol. Journal Of The Endocrine Society 2021, 5: a750-a751. DOI: 10.1210/jendso/bvab048.1526.Peer-Reviewed Original ResearchUnopposed estradiolWT miceMKR miceEndometrial adenocarcinomaNuclear atypiaExact testPlacebo-treated miceSetting of hyperinsulinemiaInsulin tolerance testingNormal-weight womenSetting of obesityEffects of estradiolCohort of miceFischer's exact testLower body weightOxidative stress-induced damagePercent body fatDNA damageBlinded histological analysisPartial hysterectomyWeight womenAnovulatory cyclesEndometrial glandsHyperinsulinemic miceCystic dilation