2019
SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride Content
Anam A, Cooke K, O'Bryan J, Flannery C. SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride Content. Journal Of The Endocrine Society 2019, 3: sat-lb041. PMCID: PMC6552031, DOI: 10.1210/js.2019-sat-lb041.Peer-Reviewed Original ResearchPlacental lipid metabolismLean womenIGF-2Triglyceride contentLipid metabolismIGF-1Maternal triglyceride levelsMean age 34.4Elective C-sectionTime of presentationInsulin receptor isoformsMultiple comparison testColorimetric spectrophotometerNeonatal complicationsPlacenta explantsMaternal obesityNeonatal adiposityPlacental lipid contentMaternal insulinObese womenPregnant womenTG levelsTriglyceride levelsEndocrine SocietyVillous explants
2018
Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.Peer-Reviewed Original ResearchConceptsGlucose metabolismGlycogen synthesisSecretory phase endometriumEndometrial epithelial cellsHuman endometrial glandsGlycogen synthase kinase 3α/βSynthase kinase 3α/βMaternal obesityHealthy womenEndometrial glandsEarly pregnancyHuman endometriumGSK3α/βOutcome measurementsSuccessful implantationFetal developmentEndometriumCritical metabolic functionsInsulinGlycogen contentProgesteroneSustain embryo developmentEpithelial cellsInsulin receptorPotential role